Ovch2 ovochymase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ovch2provided by MGI
Official Full Name: ovochymase 2provided by MGI
Primary source: MGI:MGI:3045251
See related: Ensembl:ENSMUSG00000048236 AllianceGenome:MGI:3045251
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ovtn; 9230106D23Rik
Summary: Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in epididymis; large intestine; ovary; and testis. Orthologous to human OVCH2 (ovochymase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 116.7) See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.21 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (107380751..107400386, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (107781544..107801179, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
Title: CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ovochymase-2

Names: oviductin

NP_766496.2

EC 3.4.21.120

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172908.3 → NP_766496.2 ovochymase-2 precursor

See identical proteins and their annotated locations for NP_766496.2

Status: VALIDATED

Source sequence(s)

AC140431

Consensus CDS

CCDS21692.1

UniProtKB/Swiss-Prot

Q7M761, Q8BZQ8

Related

ENSMUSP00000102366.3, ENSMUST00000106755.3

Conserved Domains (3) summary

smart00020
Location:51 → 294

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:431 → 542

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00190
Location:52 → 297

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...