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    ocr-3 Ion transport domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188364, updated on 12-Jun-2024

    Summary

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    Gene symbol
    ocr-3
    Gene description
    Ion transport domain-containing protein
    Locus tag
    CELE_T10B10.7
    See related
    AllianceGenome:WB:WBGene00003840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in rectal gland cell. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ocr-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    16
    Sequence:
    Chromosome: X; NC_003284.9 (15168724..15173636)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nucleotide-diphospho-sugar transferase Neighboring gene Secreted protein Neighboring gene Peptidase M16 N-terminal domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene PH domain-containing protein;RUN domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function and regulation of TRP family channels in C. elegans. Xiao R, et al. Pflugers Arch, 2009 Sep. PMID 19421772, Free PMC Article
    2. Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Tobin DM, et al. Neuron, 2002 Jul 18. PMID 12160748
    3. Invertebrate TRP proteins as functional models for mammalian channels. Vriens J, et al. Pflugers Arch, 2004 Dec. PMID 15480752
    4. Studying TRP Channels in Caenorhabditis elegans. Zhu MX, et al. , 2011. PMID 22593955
    5. Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Glauser DA, et al. Genetics, 2011 May. PMID 21368276, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ion transport domain-containing protein
    NP_510520.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15168724..15173636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078119.8 → NP_510520.4  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510520.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22374
      Conserved Domains (2) summary
      TIGR00870
      Location:136 → 801
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:182 → 242
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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