gclm glutamate-cysteine ligase, modifier subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gclmprovided by ZNC
Official Full Name: glutamate-cysteine ligase, modifier subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5906
See related: Ensembl:ENSDARG00000018953 AllianceGenome:ZFIN:ZDB-GENE-030131-5906
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GLCLR; zgc:55903; id:ibd3182; wu:fi24c07
Summary: Predicted to enable enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (15269341..15277252)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (15231637..15239547)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW154238 (e-PCR)
- UniSTS:205918

fi24c07.x1 (e-PCR)
- UniSTS:197082

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-cysteine ligase catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate-cysteine ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of glutamate-cysteine ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamate--cysteine ligase regulatory subunit

NP_956139.1

EC 6.3.2.2

XP_009302077.1

EC 6.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199845.1 → NP_956139.1 glutamate--cysteine ligase regulatory subunit

See identical proteins and their annotated locations for NP_956139.1

Status: PROVISIONAL

Source sequence(s)

BC044532

UniProtKB/TrEMBL

Q803D0

Related

ENSDARP00000023515.6, ENSDART00000020386.7

Conserved Domains (1) summary

cl00470
Location:85 → 213

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

15269341..15277252

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009303802.3 → XP_009302077.1 glutamate--cysteine ligase regulatory subunit isoform X1

UniProtKB/TrEMBL

A0A8M3AUZ9

Conserved Domains (1) summary

cl00470
Location:85 → 255

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...