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    Arhgef28 Rho guanine nucleotide exchange factor 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361882, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Arhgef28provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 28provided by RGD
    Primary source
    RGD:1307061
    See related
    Ensembl:ENSRNOG00000016544 AllianceGenome:RGD:1307061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rgnef
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell morphogenesis and regulation of Rho protein signal transduction. Predicted to act upstream of or within central nervous system neuron axonogenesis and neurofilament cytoskeleton organization. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human ARHGEF28 (Rho guanine nucleotide exchange factor 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 176.9), Lung (RPKM 79.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef28 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (30998292..31294757, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29263888..29560595, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (25738514..26011429, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit beta, pseudogene 2 Neighboring gene small ribosomal subunit protein uS15-like Neighboring gene small nucleolar RNA SNORA40 Neighboring gene uncharacterized LOC134485583 Neighboring gene UTP15, small subunit processome component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. van Horck FP, et al. J Biol Chem, 2001 Feb 16. PMID 11058585
    2. RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Lin H, et al. Hum Mol Genet, 2005 Dec 1. PMID 16236762
    3. Control of axonal branching and synapse formation by focal adhesion kinase. Rico B, et al. Nat Neurosci, 2004 Oct. PMID 15378065, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within central nervous system neuron axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurofilament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurofilament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 28
    Names
    190 kDa guanine nucleotide exchange factor
    Rho guanine nucleotide exchange factor (GEF) 28
    Rho-guanine nucleotide exchange factor
    p190-RhoGEF
    p190RhoGEF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415065.1 → NP_001401994.1  rho guanine nucleotide exchange factor 28

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P0C6P5
      Related
      ENSRNOP00000059196.2, ENSRNOT00000065143.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      30998292..31294757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102531.2 → XP_038958459.1  rho guanine nucleotide exchange factor 28 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZW57, A6I534
      Related
      ENSRNOP00000083894.1
      Conserved Domains (4) summary
      smart00325
      Location:866 → 1055
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd14680
      Location:1100 → 1200
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
      pfam17380
      Location:1368 → 1536
      DUF5401; Family of unknown function (DUF5401)
      cd20876
      Location:659 → 719
      C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins

    2. XM_063282028.1 → XP_063138098.1  rho guanine nucleotide exchange factor 28 isoform X2

    3. XM_006231817.5 → XP_006231879.1  rho guanine nucleotide exchange factor 28 isoform X3

      UniProtKB/TrEMBL
      A0A8L2UN35
      Conserved Domains (4) summary
      smart00325
      Location:539 → 728
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:339 → 384
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14680
      Location:773 → 873
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
      pfam00169
      Location:809 → 874
      PH; PH domain

    RNA

    1. XR_010063623.1 RNA Sequence

    2. XR_010063622.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108542.1: Suppressed sequence

      Description
      NM_001108542.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6P5.1 GenPept UniProtKB/Swiss-Prot:P0C6P5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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