Svil supervillin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Svilprovided by RGD
Official Full Name: supervillinprovided by RGD
Primary source: RGD:1306354
See related: Ensembl:ENSRNOG00000018110 AllianceGenome:RGD:1306354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in several cellular components, including costamere; cytosol; and nucleus. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 505.9), Heart (RPKM 236.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (57343910..57539508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (52648502..52844114, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (55230298..55425967, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Cep3 (e-PCR)
- UniSTS:239631

RH131282 (e-PCR)
- UniSTS:214565

D10S1311E (e-PCR)
- UniSTS:151343

BF405465 (e-PCR)
- UniSTS:247915

RH133470 (e-PCR)
- UniSTS:216753

D17Rat57 (e-PCR), detects polymorphism
- UniSTS:119526

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in costamere	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: supervillin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108416.3 → NP_001101886.2 supervillin

See identical proteins and their annotated locations for NP_001101886.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6A8S3, F1M155

Related

ENSRNOP00000025037.7, ENSRNOT00000025037.9

Conserved Domains (6) summary

smart00153
Location:2130 → 2165

VHP; Villin headpiece domain

cd11280
Location:1514 → 1614

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1830 → 1935

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1393 → 1489

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1697 → 1810

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1952 → 2074

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

57343910..57539508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254030.5 → XP_006254092.1 supervillin isoform X8

See identical proteins and their annotated locations for XP_006254092.1

UniProtKB/TrEMBL

A0A8I6A8S3

Conserved Domains (6) summary

smart00153
Location:2173 → 2208

VHP; Villin headpiece domain

cd11280
Location:1557 → 1657

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1873 → 1978

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1436 → 1532

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1740 → 1853

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1995 → 2117

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_063276626.1 → XP_063132696.1 supervillin isoform X8
XM_006254031.5 → XP_006254093.1 supervillin isoform X8

See identical proteins and their annotated locations for XP_006254093.1

UniProtKB/TrEMBL

A0A8I6A8S3

Conserved Domains (6) summary

smart00153
Location:2173 → 2208

VHP; Villin headpiece domain

cd11280
Location:1557 → 1657

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1873 → 1978

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1436 → 1532

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1740 → 1853

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1995 → 2117

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600627.3 → XP_017456116.1 supervillin isoform X18

UniProtKB/TrEMBL

A0A8I6AHH0, D3ZEZ9

Related

ENSRNOP00000092895.1

Conserved Domains (6) summary

smart00153
Location:1731 → 1766

VHP; Villin headpiece domain

cd11280
Location:1115 → 1215

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1431 → 1536

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:994 → 1090

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1298 → 1411

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1553 → 1675

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_063276628.1 → XP_063132698.1 supervillin isoform X16
XM_017600626.3 → XP_017456115.1 supervillin isoform X17

UniProtKB/TrEMBL

D3ZEZ9
XM_017600625.3 → XP_017456114.1 supervillin isoform X15

UniProtKB/TrEMBL

D3ZEZ9

Conserved Domains (6) summary

smart00153
Location:1805 → 1840

VHP; Villin headpiece domain

cd11280
Location:1189 → 1289

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1505 → 1610

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1068 → 1164

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1372 → 1485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1627 → 1749

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_039095919.2 → XP_038951847.1 supervillin isoform X14

UniProtKB/TrEMBL

D3ZEZ9

Conserved Domains (6) summary

smart00153
Location:1832 → 1867

VHP; Villin headpiece domain

cd11280
Location:1216 → 1316

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1532 → 1637

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1095 → 1191

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1399 → 1512

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1654 → 1776

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600623.3 → XP_017456112.1 supervillin isoform X12

UniProtKB/TrEMBL

D3ZEZ9
XM_039095918.2 → XP_038951846.1 supervillin isoform X11

UniProtKB/TrEMBL

D3ZEZ9

Conserved Domains (6) summary

smart00153
Location:1887 → 1922

VHP; Villin headpiece domain

cd11280
Location:1271 → 1371

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1587 → 1692

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1150 → 1246

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1454 → 1567

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1709 → 1831

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600615.3 → XP_017456104.1 supervillin isoform X1

UniProtKB/TrEMBL

A0A8I6A8S3, A0A8I6AVE6

Related

ENSRNOP00000097742.1

Conserved Domains (6) summary

smart00153
Location:2172 → 2207

VHP; Villin headpiece domain

cd11280
Location:1556 → 1656

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1872 → 1977

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1435 → 1531

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1739 → 1852

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1994 → 2116

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600624.3 → XP_017456113.1 supervillin isoform X13

UniProtKB/TrEMBL

D3ZEZ9

Conserved Domains (6) summary

smart00153
Location:1833 → 1868

VHP; Villin headpiece domain

cd11280
Location:1217 → 1317

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1533 → 1638

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1096 → 1192

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1400 → 1513

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1655 → 1777

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600621.3 → XP_017456110.1 supervillin isoform X10

UniProtKB/TrEMBL

D3ZEZ9

Related

ENSRNOP00000062712.4
XM_063276627.1 → XP_063132697.1 supervillin isoform X9
XM_063276625.1 → XP_063132695.1 supervillin isoform X7
XM_017600619.3 → XP_017456108.1 supervillin isoform X5

UniProtKB/TrEMBL

A0A8I5ZKD0

Conserved Domains (6) summary

smart00153
Location:2118 → 2153

VHP; Villin headpiece domain

cd11280
Location:1502 → 1602

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1818 → 1923

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1381 → 1477

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1685 → 1798

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1940 → 2062

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_063276624.1 → XP_063132694.1 supervillin isoform X6

UniProtKB/TrEMBL

A0A8I5ZT25
XM_017600617.3 → XP_017456106.1 supervillin isoform X3

UniProtKB/TrEMBL

A0A8I6A8S3

Conserved Domains (6) summary

smart00153
Location:2141 → 2176

VHP; Villin headpiece domain

cd11280
Location:1525 → 1625

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1841 → 1946

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1404 → 1500

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1708 → 1821

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1963 → 2085

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600618.3 → XP_017456107.1 supervillin isoform X4

UniProtKB/TrEMBL

A0A8I6A8S3

Conserved Domains (6) summary

smart00153
Location:2131 → 2166

VHP; Villin headpiece domain

cd11280
Location:1515 → 1615

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1831 → 1936

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1394 → 1490

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1698 → 1811

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1953 → 2075

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_017600616.3 → XP_017456105.1 supervillin isoform X2

UniProtKB/TrEMBL

A0A8I6A8S3

Conserved Domains (6) summary

smart00153
Location:2147 → 2182

VHP; Villin headpiece domain

cd11280
Location:1531 → 1631

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1847 → 1952

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1410 → 1506

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1714 → 1827

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:1969 → 2091

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains