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    Tgm7 transglutaminase 7 [ Mus musculus (house mouse) ]

    Gene ID: 640543, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tgm7provided by MGI
    Official Full Name
    transglutaminase 7provided by MGI
    Primary source
    MGI:MGI:2151164
    See related
    Ensembl:ENSMUSG00000079103 AllianceGenome:MGI:2151164
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGz; TGMZ
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Is expressed in gland and pancreas. Orthologous to human TGM7 (transglutaminase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tgm7 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120923979..120946877, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121093498..121116396, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene STARR-seq mESC enhancer starr_05521 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 5 Neighboring gene predicted gene, 23858 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. Grenard P, et al. J Biol Chem, 2001 Aug 31. PMID 11390390
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide cross-linking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase Z
    NP_001153896.1
    XP_006500051.1
    XP_011238031.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160424.1 → NP_001153896.1  protein-glutamine gamma-glutamyltransferase Z

      See identical proteins and their annotated locations for NP_001153896.1

      Status: PROVISIONAL

      Source sequence(s)
      AL845479
      Consensus CDS
      CCDS89542.1
      UniProtKB/TrEMBL
      A0A571BDB6, A2ART8
      Related
      ENSMUSP00000106303.3, ENSMUST00000110675.3
      Conserved Domains (4) summary
      smart00460
      Location:272 → 364
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:275 → 370
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:8 → 122
      Transglut_N; Transglutaminase family
      pfam00927
      Location:608 → 706
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120923979..120946877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239729.1 → XP_011238031.1  protein-glutamine gamma-glutamyltransferase Z isoform X1

      See identical proteins and their annotated locations for XP_011238031.1

      Conserved Domains (2) summary
      smart00460
      Location:1 → 75
      TGc; Transglutaminase/protease-like homologues
      pfam00927
      Location:319 → 416
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    2. XM_006499988.2 → XP_006500051.1  protein-glutamine gamma-glutamyltransferase Z isoform X1

      See identical proteins and their annotated locations for XP_006500051.1

      Conserved Domains (2) summary
      smart00460
      Location:1 → 75
      TGc; Transglutaminase/protease-like homologues
      pfam00927
      Location:319 → 416
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    Nucleotide Protein
    Heading Accession and Version

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