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    Gpatch8 G patch domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685233, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gpatch8provided by RGD
    Official Full Name
    G patch domain containing 8provided by RGD
    Primary source
    RGD:1596463
    See related
    Ensembl:ENSRNOG00000021044 AllianceGenome:RGD:1596463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity and nucleic acid binding activity. Predicted to be active in nucleus. Orthologous to human GPATCH8 (G-patch domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 63.7), Adrenal (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpatch8 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87932174..88012523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87432020..87512594, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90421443..90501996, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A2 Neighboring gene integrin subunit alpha 2b Neighboring gene uncharacterized LOC134480882 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC102550111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G patch domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398883.1 → NP_001385812.1  G patch domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6G8E6, F1M4M5
      Related
      ENSRNOP00000047081.5, ENSRNOT00000050474.6
      Conserved Domains (4) summary
      PTZ00449
      Location:1054 → 1327
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK03918
      Location:82 → 207
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam01585
      Location:40 → 82
      G-patch; G-patch domain
      pfam12171
      Location:136 → 163
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87932174..88012523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087760.2 → XP_038943688.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6
      Conserved Domains (3) summary
      PTZ00449
      Location:976 → 1249
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. XM_039087763.2 → XP_038943691.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6
      Conserved Domains (3) summary
      PTZ00449
      Location:976 → 1249
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. XM_063269835.1 → XP_063125905.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6

    4. XM_039087761.2 → XP_038943689.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6
      Conserved Domains (3) summary
      PTZ00449
      Location:976 → 1249
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    5. XM_063269837.1 → XP_063125907.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6

    6. XM_063269838.1 → XP_063125908.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6

    7. XM_039087766.2 → XP_038943694.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6
      Conserved Domains (3) summary
      PTZ00449
      Location:976 → 1249
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    8. XM_017597723.3 → XP_017453212.1  G patch domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8E6
      Conserved Domains (3) summary
      PTZ00449
      Location:976 → 1249
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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