dnaaf4 dynein axonemal assembly factor 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnaaf4provided by ZNC
Official Full Name: dynein axonemal assembly factor 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1892
See related: Ensembl:ENSDARG00000099161 AllianceGenome:ZFIN:ZDB-GENE-040426-1892
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: EKN1; dyx1c1; zgc:77853
Summary: Predicted to enable estrogen receptor binding activity. Acts upstream of or within cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; and left/right axis specification. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (2169144..2180811)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (2883021..2894688)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.
Title: Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.
DYX1C1 is required for axonemal dynein assembly and ciliary motility.
Title: DYX1C1 is required for axonemal dynein assembly and ciliary motility.
In dyx1c1 morphants, cilia length is reduced in several organs including Kupffer's vesicle, pronephros, spinal canal and olfactory placode.
Title: The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nuclear estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cilium movement involved in extracellular fluid movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within left/right axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein assembly factor 4, axonemal

Names: dyslexia susceptibility 1 candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205688.1 → NP_991251.1 dynein assembly factor 4, axonemal

See identical proteins and their annotated locations for NP_991251.1

Status: PROVISIONAL

Source sequence(s)

BC065881

UniProtKB/TrEMBL

Q6P010

Related

ENSDARP00000130956.1, ENSDART00000165855.2

Conserved Domains (5) summary

cd06469
Location:10 → 87

p23_DYX1C1_like; p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD ...

sd00006
Location:286 → 314

TPR; TPR repeat [structural motif]

pfam00515
Location:363 → 395

TPR_1; Tetratricopeptide repeat

pfam13414
Location:285 → 349

TPR_11; TPR repeat

pfam13424
Location:316 → 393

TPR_12; Tetratricopeptide repeat