Gtf3c2 general transcription factor IIIC, polypeptide 2, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtf3c2provided by MGI
Official Full Name: general transcription factor IIIC, polypeptide 2, betaprovided by MGI
Primary source: MGI:MGI:1919002
See related: Ensembl:ENSMUSG00000106864 AllianceGenome:MGI:1919002
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TFIIIC110; mKIAA0011; 1300004C11Rik; 2610510G03Rik
Summary: Predicted to contribute to DNA binding activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human GTF3C2 (general transcription factor IIIC subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 28.4), CNS E11.5 (RPKM 24.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.15 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31313350..31337488, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31156006..31180144, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE109729 (e-PCR)
- UniSTS:248331

RH135975 (e-PCR)
- UniSTS:209971

Gtf3c2 (e-PCR), detects polymorphism
- UniSTS:506962

RH126221 (e-PCR)
- UniSTS:162929

AU041069 (e-PCR)
- UniSTS:159357

NoName (e-PCR)
- UniSTS:235156

NoName (e-PCR)
- UniSTS:235157

RH131179 (e-PCR)
- UniSTS:214462

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIIC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: general transcription factor 3C polypeptide 2

Names: TF3C-beta; TFIIIC 110 kDa subunit; TFIIIC-BETA; transcription factor IIIC 110 kDa subunit; transcription factor IIIC subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027901.2 → NP_082177.2 general transcription factor 3C polypeptide 2

See identical proteins and their annotated locations for NP_082177.2

Status: VALIDATED

Source sequence(s)

AK012095, AK083585, AK152439

Consensus CDS

CCDS39053.1

UniProtKB/Swiss-Prot

Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BL74, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6

UniProtKB/TrEMBL

D3Z7I0

Related

ENSMUSP00000085325.6, ENSMUST00000088010.12

Conserved Domains (4) summary

smart00527
Location:166 → 243

HMG17; domain in high mobilty group proteins HMG14 and HMG 17

COG2319
Location:554 → 719

WD40; WD40 repeat [General function prediction only]

sd00039
Location:554 → 591

7WD40; WD40 repeat [structural motif]

cl02567
Location:555 → 640

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...