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    ING1 inhibitor of growth family member 1 [ Homo sapiens (human) ]

    Gene ID: 3621, updated on 2-May-2024

    Summary

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    Official Symbol
    ING1provided by HGNC
    Official Full Name
    inhibitor of growth family member 1provided by HGNC
    Primary source
    HGNC:HGNC:6062
    See related
    Ensembl:ENSG00000153487 MIM:601566; AllianceGenome:HGNC:6062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
    Summary
    This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 5.0), endometrium (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ING1 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (110712623..110723339)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (109942828..109953552)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111364970..111375686)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8003 Neighboring gene Sharpr-MPRA regulatory region 8993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111183105-111183721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111186543-111187325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5502 Neighboring gene RAB20, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111209741-111210264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111210265-111210787 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111213668-111213857 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:111253624-111254492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111262660-111263160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111263161-111263661 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111266973-111267900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8005 Neighboring gene NAXD antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111284913-111285575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111286570-111287399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111287400-111288228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111289059-111289887 Neighboring gene NAD(P)HX dehydratase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111301435-111301934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8006 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8011 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111364717-111364885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8013 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111368201-111368894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111371617-111372308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8015 Neighboring gene uncharacterized LOC107984613 Neighboring gene ribosomal protein L21 pseudogene 107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of miR-500 and miR-628 suppress non-small cell lung cancer proliferation, migration and invasion by targeting ING1. Jiang M, et al. Biomed Pharmacother, 2018 Dec. PMID 30372865
    2. Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma. Wang X, et al. Cell Death Dis, 2018 Oct 9. PMID 30302016, Free PMC Article
    3. The ING1a model of rapid cell senescence. Bertschmann J, et al. Mech Ageing Dev, 2019 Jan. PMID 29928906
    4. ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization. Rajarajacholan UK, et al. Nucleic Acids Res, 2017 Feb 28. PMID 27903908, Free PMC Article
    5. Aging with ING: a comparative study of different forms of stress induced premature senescence. Rajarajacholan UK, et al. Oncotarget, 2015 Oct 27. PMID 26439691, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat.
      Title: ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat.
    2. ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
      Title: ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
    3. CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity.
      Title: CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity.
    4. miR-24-3p promotes colon cancer progression by targeting ING1.
      Title: miR-24-3p promotes colon cancer progression by targeting ING1.
    5. Emerging Role of C/EBPbeta and Epigenetic DNA Methylation in Ageing.
      Title: Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing.
    6. Nitazoxanide as an autophagy inhibitor induces cell cycle arrest in glioblastoma via upregulated ING1.
      Title: Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma.
    7. ING1a induces these changes through strongly inhibiting endocytosis to block mitogen signaling by inducing the expression of intersectin 2, a key scaffolding protein of the endosomal pathway.
      Title: The ING1a model of rapid cell senescence.
    8. Over-expression of ING1 dramatically inhibited non-small cell lung cancer cells proliferation, migration and invasion.
      Title: Down-regulation of miR-500 and miR-628 suppress non-small cell lung cancer proliferation, migration and invasion by targeting ING1.
    9. The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A.
      Title: p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man.
    10. Nuclear entrapment of p33ING1b by inhibition of exportin-1 triggers apoptosis in head and neck squamous cell cancer cells.
      Title: Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (75)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Squamous cell carcinoma of the head and neck
    MedGen: C1168401 OMIM: 275355 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of growth protein 1
    Names
    growth inhibitor ING1
    growth inhibitory protein ING1
    tumor suppressor ING1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012197.2 RefSeqGene

      Range
      6079..15718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267728.1 → NP_001254657.1  inhibitor of growth protein 1 isoform E

      See identical proteins and their annotated locations for NP_001254657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal segment in the 5' coding region, compared to variant 4. The resulting isoform (E) lacks an internal segment, as compared to isoform D.
      Source sequence(s)
      AB037594, BC018348, DB537640
      UniProtKB/Swiss-Prot
      Q9UK53
      Conserved Domains (2) summary
      cd15584
      Location:195 → 239
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      pfam12998
      Location:29 → 94
      ING; Inhibitor of growth proteins N-terminal histone-binding

    2. NM_005537.5 → NP_005528.4  inhibitor of growth protein 1 isoform D

      See identical proteins and their annotated locations for NP_005528.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (D).
      Source sequence(s)
      AI016573, AL157820, BC018348, KF455830
      Consensus CDS
      CCDS9517.1
      UniProtKB/Swiss-Prot
      O00532, O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0, Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, Q9P0U6, Q9UBC6, Q9UIJ1, Q9UIJ2, Q9UIJ3, Q9UIJ4, Q9UK52, Q9UK53
      UniProtKB/TrEMBL
      A0A0C4DFW2
      Related
      ENSP00000364929.3, ENST00000375774.3
      Conserved Domains (2) summary
      cd15584
      Location:355 → 399
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      pfam12998
      Location:189 → 254
      ING; Inhibitor of growth proteins N-terminal histone-binding

    3. NM_198217.3 → NP_937860.1  inhibitor of growth protein 1 isoform C

      See identical proteins and their annotated locations for NP_937860.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' end-region, which includes part of the coding region, compared to variant 4. The resulting isoform (C) has a shorter N-terminus, as compared to isoform D.
      Source sequence(s)
      AL157820
      Consensus CDS
      CCDS9515.1
      UniProtKB/Swiss-Prot
      Q9UK53
      Related
      ENSP00000345202.7, ENST00000338450.7
      Conserved Domains (2) summary
      cd15584
      Location:168 → 212
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      cl28919
      Location:2 → 63
      ING; Inhibitor of growth (ING) domain family

    4. NM_198218.3 → NP_937861.1  inhibitor of growth protein 1 isoform B

      See identical proteins and their annotated locations for NP_937861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' end-region and uses a downstream in-frame start codon, compared to variant 4. The resulting isoform (B) has a shorter N-terminus, as compared to isoform D.
      Source sequence(s)
      AL157820
      Consensus CDS
      CCDS9518.1
      UniProtKB/Swiss-Prot
      Q9UK53
      Related
      ENSP00000364930.3, ENST00000375775.4
      Conserved Domains (2) summary
      cd15584
      Location:143 → 187
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      cl28919
      Location:1 → 38
      ING; Inhibitor of growth (ING) domain family

    5. NM_198219.3 → NP_937862.1  inhibitor of growth protein 1 isoform A

      See identical proteins and their annotated locations for NP_937862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' end-region, which includes part of the coding region, compared to variant 4. The resulting isoform (A) has a distinct and shorter N-terminus, as compared to isoform D.
      Source sequence(s)
      AL157820
      Consensus CDS
      CCDS9516.1
      UniProtKB/Swiss-Prot
      Q9UK53
      Related
      ENSP00000328436.8, ENST00000333219.9
      Conserved Domains (2) summary
      cd15584
      Location:212 → 256
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      cd16860
      Location:20 → 107
      ING_ING1; Inhibitor of growth (ING) domain of inhibitor of growth protein 1 (ING1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      110712623..110723339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      109942828..109953552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK53.2 GenPept UniProtKB/Swiss-Prot:Q9UK53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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