CNTNAP4 contactin associated protein family member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CNTNAP4provided by HGNC
Official Full Name: contactin associated protein family member 4provided by HGNC
Primary source: HGNC:HGNC:18747
See related: Ensembl:ENSG00000152910 MIM:610518; AllianceGenome:HGNC:18747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CASPR4
Summary: This gene encodes a member of the neurexin protein family. Members of this family function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. This protein may also play a role in proper neurotransmission in the dopaminergic and GABAergic systems and mutations in this gene may be associated with certain psychiatric illnesses. A polymorphism in an intron of this gene may be associated with longevity. [provided by RefSeq, Apr 2016]
Expression: Biased expression in brain (RPKM 7.4) and adrenal (RPKM 0.3) See more
Orthologs: mouse all
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Genomic context

Location:: 16q23.1

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (76277401..76560757)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (82333540..82616946)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (76311299..76594654)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
Title: Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
Title: CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
we demonstrated that the expression of contactin-associated protein-like 4 (CNTNAP4) was decreased in the temporal neocortex of epileptic patients
Title: CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation: Evidence From Temporal Lobe Epilepsy Patients and Mouse Models.
This study is the first demonstration for association of the CNTNAP4 gene and one of its intronic CNV polymorphisms with aging.
Title: A common copy number variation (CNV) polymorphism in the CNTNAP4 gene: association with aging in females.
A quantitative analysis of central corneal thickness and a subsequent analysis of primary open-angle glaucoma (POAG), SNPs in two cell adhesion molecules, NTM and CNTNAP4, were identified and may increase POAG susceptibility in a subset of cases.
Title: Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNF&#x003b1; inhibitors in patients with rheumatoid arthritis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S515 (e-PCR), detects polymorphism
- UniSTS:41738

D16S515 (e-PCR), detects polymorphism
- UniSTS:28732

SHGC-82903 (e-PCR)
- UniSTS:96092

D16S2890 (e-PCR)
- UniSTS:153460

D16S3118 (e-PCR), detects polymorphism
- UniSTS:10357

RH122580 (e-PCR)
- UniSTS:138643

D16S3083 (e-PCR), detects polymorphism
- UniSTS:78238

D16S742 (e-PCR)
- UniSTS:61121

SHGC-155721 (e-PCR)
- UniSTS:182997

RH118447 (e-PCR)
- UniSTS:109274

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of grooming behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic transmission, dopaminergic	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: contactin-associated protein-like 4

Names: cell recognition molecule Caspr4; contactin associated protein like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001322178.2 → NP_001309107.1 contactin-associated protein-like 4 isoform 3

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

UniProtKB/TrEMBL

A0A0A0MR20

Conserved Domains (9) summary

smart00231
Location:55 → 177

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:912 → 946

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:54 → 176

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:744 → 888

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:503 → 534

EGF; EGF-like domain

pfam02210
Location:212 → 341

Laminin_G_2; Laminin G domain

cl00085
Location:542 → 589

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:554 → 637

COLFI; Fibrillar collagen C-terminal domain

cl22861
Location:371 → 429

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001322179.2 → NP_001309108.1 contactin-associated protein-like 4 isoform 4

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

UniProtKB/TrEMBL

A0A0A0MR20

Conserved Domains (7) summary

smart00231
Location:55 → 177

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:54 → 176

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:371 → 521

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:553 → 584

EGF; EGF-like domain

pfam02210
Location:212 → 341

Laminin_G_2; Laminin G domain

cl00085
Location:592 → 639

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:604 → 687

COLFI; Fibrillar collagen C-terminal domain
NM_001322180.2 → NP_001309109.1 contactin-associated protein-like 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

UniProtKB/TrEMBL

A0A0A0MR20

Conserved Domains (8) summary

smart00231
Location:3 → 48

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:833 → 867

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:3 → 47

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:665 → 809

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:424 → 455

EGF; EGF-like domain

pfam02210
Location:83 → 212

Laminin_G_2; Laminin G domain

cl00085
Location:463 → 510

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:475 → 558

COLFI; Fibrillar collagen C-terminal domain
NM_001322181.2 → NP_001309110.1 contactin-associated protein-like 4 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

UniProtKB/TrEMBL

A0A0A0MR20

Conserved Domains (8) summary

smart00231
Location:55 → 176

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:961 → 995

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:54 → 175

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:793 → 937

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:552 → 583

EGF; EGF-like domain

pfam02210
Location:211 → 340

Laminin_G_2; Laminin G domain

cl00085
Location:591 → 638

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:603 → 686

COLFI; Fibrillar collagen C-terminal domain
NM_001322187.2 → NP_001309116.1 contactin-associated protein-like 4 isoform 7

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

Conserved Domains (7) summary

cd00054
Location:490 → 524

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:322 → 466

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:81 → 112

EGF; EGF-like domain

pfam02210
Location:574 → 704

Laminin_G_2; Laminin G domain

cl00085
Location:120 → 167

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:132 → 215

COLFI; Fibrillar collagen C-terminal domain

cl22861
Location:2 → 52

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001322188.2 → NP_001309117.1 contactin-associated protein-like 4 isoform 8

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

UniProtKB/TrEMBL

A0A0A0MR20

Conserved Domains (8) summary

smart00231
Location:55 → 177

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:962 → 996

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:54 → 176

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:794 → 938

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:553 → 584

EGF; EGF-like domain

pfam02210
Location:212 → 341

Laminin_G_2; Laminin G domain

cl00085
Location:592 → 639

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:604 → 687

COLFI; Fibrillar collagen C-terminal domain
NM_001322189.2 → NP_001309118.1 contactin-associated protein-like 4 isoform 9

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

UniProtKB/TrEMBL

A0A0A0MR20

Conserved Domains (8) summary

smart00231
Location:3 → 89

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:874 → 908

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:1 → 88

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:706 → 850

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:465 → 496

EGF; EGF-like domain

pfam02210
Location:124 → 253

Laminin_G_2; Laminin G domain

cl00085
Location:504 → 551

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:516 → 599

COLFI; Fibrillar collagen C-terminal domain
NM_001322190.2 → NP_001309119.1 contactin-associated protein-like 4 isoform 10

Status: REVIEWED

Source sequence(s)

AB100092, AC106741, AC108125, FO681478

Consensus CDS

CCDS82015.1

UniProtKB/TrEMBL

A0A087WTA1, F5H107

Related

ENSP00000477698.1, ENST00000622250.4

Conserved Domains (8) summary

smart00231
Location:55 → 177

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:914 → 948

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:54 → 176

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:746 → 890

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:505 → 536

EGF; EGF-like domain

pfam02210
Location:998 → 1128

Laminin_G_2; Laminin G domain

cl00085
Location:544 → 591

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:556 → 639

COLFI; Fibrillar collagen C-terminal domain
NM_001322191.2 → NP_001309120.1 contactin-associated protein-like 4 isoform 11

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

Conserved Domains (7) summary

cd00054
Location:653 → 687

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:485 → 629

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:244 → 275

EGF; EGF-like domain

pfam02210
Location:737 → 867

Laminin_G_2; Laminin G domain

cl00085
Location:283 → 330

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:295 → 378

COLFI; Fibrillar collagen C-terminal domain

cl22861
Location:1 → 32

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_033401.5 → NP_207837.2 contactin-associated protein-like 4 isoform 1 precursor

See identical proteins and their annotated locations for NP_207837.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AB051550, AC106741, AC108125, BM544789, Z44514

Consensus CDS

CCDS73915.1

UniProtKB/Swiss-Prot

E9PFZ6, Q86YZ7, Q9C0A0

UniProtKB/TrEMBL

A0A0A0MR20

Related

ENSP00000479811.1, ENST00000611870.5

Conserved Domains (7) summary

cd00054
Location:962 → 996

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:54 → 176

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:794 → 938

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:553 → 584

EGF; EGF-like domain

pfam02210
Location:212 → 341

Laminin_G_2; Laminin G domain

cl00085
Location:592 → 639

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:604 → 687

COLFI; Fibrillar collagen C-terminal domain
NM_138994.5 → NP_620481.2 contactin-associated protein-like 4 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and CDS and lacks several coding exons, compared to variant 1. It encodes a shorter protein (isoform 2) which has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB100093, AC106741, AC108125, DA319383, DB050637, DT217898

Consensus CDS

CCDS10924.2

UniProtKB/TrEMBL

F5H107

Related

ENSP00000418741.1, ENST00000478060.5

Conserved Domains (8) summary

smart00231
Location:30 → 152

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:889 → 923

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:29 → 151

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:721 → 865

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:480 → 511

EGF; EGF-like domain

pfam02210
Location:973 → 1103

Laminin_G_2; Laminin G domain

cl00085
Location:519 → 566

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:531 → 614

COLFI; Fibrillar collagen C-terminal domain

RNA

NR_136210.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478
NR_136213.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478
NR_136216.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC010528, AC106741, AC108125, FO681478

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

76277401..76560757

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047434819.1 → XP_047290775.1 contactin-associated protein-like 4 isoform X2

UniProtKB/TrEMBL

Q96M80
XM_011523403.3 → XP_011521705.1 contactin-associated protein-like 4 isoform X1

UniProtKB/TrEMBL

A0A0A0MR20

Related

ENSP00000417628.1, ENST00000476707.1

Conserved Domains (8) summary

smart00231
Location:30 → 152

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:937 → 971

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:29 → 151

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:769 → 913

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:528 → 559

EGF; EGF-like domain

pfam02210
Location:187 → 316

Laminin_G_2; Laminin G domain

cl00085
Location:567 → 614

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02436
Location:579 → 662

COLFI; Fibrillar collagen C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

82333540..82616946

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314225.1 → XP_054170200.1 contactin-associated protein-like 4 isoform X2

UniProtKB/TrEMBL

Q96M80
XM_054314224.1 → XP_054170199.1 contactin-associated protein-like 4 isoform X3

UniProtKB/TrEMBL

A0A0A0MR20