Myo16 myosin XVI [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo16provided by RGD
Official Full Name: myosin XVIprovided by RGD
Primary source: RGD:621561
See related: Ensembl:ENSRNOG00000016483 AllianceGenome:RGD:621561
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myr8
Summary: Enables actin filament binding activity and protein phosphatase binding activity. Involved in cerebellum development; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of cell population proliferation. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Part of myosin complex. Orthologous to human MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 46.2), Heart (RPKM 12.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (85586428..86066537, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (78884405..79364445, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (84575149..85177834, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo16 may play a regulatory role in cell cycle progression.
Title: Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138613 (e-PCR)
- UniSTS:220700

BF388471 (e-PCR)
- UniSTS:244955

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-XVI

Names: myosin heavy chain Myr 8; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; unconventional myosin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138893.2 → NP_620248.1 unconventional myosin-XVI

See identical proteins and their annotated locations for NP_620248.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q9ERC1, Q9QXI0

UniProtKB/TrEMBL

A0A8I6ANW7, A6IWR4

Related

ENSRNOP00000022741.4, ENSRNOT00000022742.4

Conserved Domains (6) summary

smart00242
Location:403 → 1139

MYSc; Myosin. Large ATPases

COG0666
Location:64 → 310

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:120 → 275

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14878
Location:415 → 1132

MYSc_Myo16; class XVI myosin, motor domain

pfam15439
Location:1224 → 1581

NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

sd00045
Location:221 → 252

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

85586428..86066537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599990.3 → XP_017455479.1 unconventional myosin-XVI isoform X3

UniProtKB/Swiss-Prot

Q9ERC1, Q9QXI0

UniProtKB/TrEMBL

A0A8I6ANW7, A6IWR4

Conserved Domains (6) summary

smart00242
Location:403 → 1139

MYSc; Myosin. Large ATPases

COG0666
Location:64 → 310

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:120 → 275

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14878
Location:415 → 1132

MYSc_Myo16; class XVI myosin, motor domain

pfam15439
Location:1224 → 1581

NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

sd00045
Location:221 → 252

ANK; ANK repeat [structural motif]
XM_039094188.2 → XP_038950116.1 unconventional myosin-XVI isoform X2

UniProtKB/TrEMBL

A0A8I6ANW7

Conserved Domains (4) summary

cd14878
Location:436 → 1153

MYSc_Myo16; class XVI myosin, motor domain

sd00045
Location:243 → 274

ANK; ANK repeat [structural motif]

pfam15439
Location:1235 → 1602

NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

cl39094
Location:101 → 302

Ank_2; Ankyrin repeats (3 copies)
XM_008771384.4 → XP_008769606.1 unconventional myosin-XVI isoform X1

UniProtKB/TrEMBL

A0A8I6ANW7

Conserved Domains (6) summary

smart00242
Location:425 → 1161

MYSc; Myosin. Large ATPases

COG0666
Location:86 → 332

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:142 → 297

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14878
Location:437 → 1154

MYSc_Myo16; class XVI myosin, motor domain

pfam15439
Location:1246 → 1603

NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

sd00045
Location:243 → 274

ANK; ANK repeat [structural motif]