Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lgr6provided by RGD
Official Full Name: leucine-rich repeat-containing G protein-coupled receptor 6provided by RGD
Primary source: RGD:1560339
See related: Ensembl:ENSRNOG00000005093 AllianceGenome:RGD:1560339
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560339
Summary: Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in several processes, including axon guidance; negative chemotaxis; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within bone regeneration. Predicted to be located in vesicle. Orthologous to human LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 53.6), Lung (RPKM 11.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48976193..49095870, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (46424382..46544074, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51811904..51931193, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138120 (e-PCR)
- UniSTS:220207

RH64613 (e-PCR)
- UniSTS:42050

D13Rat176 (e-PCR), detects polymorphism
- UniSTS:226551

41.MMHAP33FRF11.seq (e-PCR)
- UniSTS:124408

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue regeneration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427357.2 → NP_001414286.1 leucine-rich repeat-containing G-protein coupled receptor 6 precursor

Status: INFERRED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ICD4, D3ZJU9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

48976193..49095870 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091316.2 → XP_038947244.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

UniProtKB/TrEMBL

A6ICD4

Conserved Domains (5) summary

smart00013
Location:34 → 68

LRRNT; Leucine rich repeat N-terminal domain

PLN00113
Location:60 → 429

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:330 → 344

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:70 → 91

LRR_RI; leucine-rich repeat [structural motif]

cd15362
Location:520 → 796

7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs