Pex7 peroxisomal biogenesis factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pex7provided by RGD
Official Full Name: peroxisomal biogenesis factor 7provided by RGD
Primary source: RGD:1308483
See related: Ensembl:ENSRNOG00000012322 AllianceGenome:RGD:1308483
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity; peroxisome matrix targeting signal-2 binding activity; and protein homodimerization activity. Predicted to be involved in ether lipid biosynthetic process and protein import into peroxisome matrix. Predicted to act upstream of or within several processes, including endochondral ossification; fatty acid beta-oxidation; and protein targeting to peroxisome. Predicted to be located in peroxisome. Predicted to be active in cytosol and peroxisomal matrix. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and rhizomelic chondrodysplasia punctata type 1. Orthologous to human PEX7 (peroxisomal biogenesis factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 84.9), Kidney (RPKM 82.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (16402319..16466304, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (14582698..14646686, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (15311768..15374702, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S2827 (e-PCR), detects polymorphism
- UniSTS:50739

RH143523 (e-PCR)
- UniSTS:232769

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables peroxisome matrix targeting signal-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome matrix targeting signal-2 binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in ether lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting to peroxisome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal biogenesis factor 7

Names: peroxisome biogenesis factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034147.1 → NP_001029319.1 peroxisomal biogenesis factor 7

See identical proteins and their annotated locations for NP_001029319.1

Status: PROVISIONAL

Source sequence(s)

BC100091

UniProtKB/TrEMBL

A0A8I5Y6K4, A6JPB8, Q498S5

Related

ENSRNOP00000016728.5, ENSRNOT00000016728.8

Conserved Domains (3) summary

COG2319
Location:41 → 311

WD40; WD40 repeat [General function prediction only]

cd00200
Location:63 → 310

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:65 → 104

7WD40; WD40 repeat [structural motif]