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    Hao2 hydroxyacid oxidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84029, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Hao2provided by RGD
    Official Full Name
    hydroxyacid oxidase 2provided by RGD
    Primary source
    RGD:70972
    See related
    Ensembl:ENSRNOG00000019470 AllianceGenome:RGD:70972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hao3; LCHAO
    Summary
    Enables (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and identical protein binding activity. Involved in mandelate metabolic process. Located in peroxisome. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 10819.9), Adrenal (RPKM 1700.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hao2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (188888848..188921567, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (186200137..186232997, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (200785492..200808868)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 Neighboring gene uncharacterized LOC120100894 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene small nucleolar RNA SNORA44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure analysis of recombinant rat kidney long chain hydroxy acid oxidase. Cunane LM, et al. Biochemistry, 2005 Feb 8. PMID 15683236
    2. Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci. Lee SJ, et al. Hypertens Res, 2003 Jan. PMID 12661916
    3. Molecular cloning and nucleotide sequence of cDNA encoding rat kidney long-chain L-2-hydroxy acid oxidase. Expression of the catalytically active recombinant protein as a chimaera. Belmouden A, et al. Eur J Biochem, 1993 May 15. PMID 8508789
    4. Rat kidney L-2-hydroxyacid oxidase. Structural and mechanistic comparison with flavocytochrome b2 from baker's yeast. Urban P, et al. Biochemistry, 1988 Sep 20. PMID 3061453
    5. Amino acid sequence of long chain alpha-hydroxy acid oxidase from rat kidney, a member of the family of FMN-dependent alpha-hydroxy acid-oxidizing enzymes. Diêp Lê KH, et al. J Biol Chem, 1991 Nov 5. PMID 1939137

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma (HCC).
      Title: The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (S)-2-hydroxy-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (S)-2-hydroxy-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables (S)-2-hydroxy-acid oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mandelate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-Hydroxyacid oxidase 2
    Names
    (S)-2-hydroxy-acid oxidase, peroxisomal
    HAOX2
    hydroxyacid oxidase 2 (long chain)
    hydroxyacid oxidase 3 (medium-chain)
    long chain alpha-hydroxy acid oxidase
    long-chain L-2-hydroxy acid oxidase
    NP_114471.1
    XP_006233084.1
    XP_006233086.1
    XP_006233087.1
    XP_038959191.1
    XP_063138713.1
    XP_063138714.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032082.2 → NP_114471.1  2-Hydroxyacid oxidase 2

      See identical proteins and their annotated locations for NP_114471.1

      Status: PROVISIONAL

      Source sequence(s)
      X67156
      UniProtKB/Swiss-Prot
      Q07523
      UniProtKB/TrEMBL
      A0A0G2K713, A6K3E3
      Related
      ENSRNOP00000040223.1, ENSRNOT00000046942.3
      Conserved Domains (2) summary
      cd02809
      Location:7 → 345
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
      pfam01070
      Location:14 → 349
      FMN_dh; FMN-dependent dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      188888848..188921567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282644.1 → XP_063138714.1  2-Hydroxyacid oxidase 2 isoform X5

      UniProtKB/Swiss-Prot
      Q07523
      UniProtKB/TrEMBL
      A0A0G2K713, A6K3E3

    2. XM_039103263.2 → XP_038959191.1  2-Hydroxyacid oxidase 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K713
      Conserved Domains (1) summary
      pfam01070
      Location:13 → 352
      FMN_dh; FMN-dependent dehydrogenase

    3. XM_006233025.5 → XP_006233087.1  2-Hydroxyacid oxidase 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K713
      Conserved Domains (1) summary
      pfam01070
      Location:13 → 352
      FMN_dh; FMN-dependent dehydrogenase

    4. XM_006233024.5 → XP_006233086.1  2-Hydroxyacid oxidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K713
      Conserved Domains (2) summary
      cd02809
      Location:18 → 356
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
      pfam01070
      Location:25 → 360
      FMN_dh; FMN-dependent dehydrogenase

    5. XM_063282643.1 → XP_063138713.1  2-Hydroxyacid oxidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K713

    6. XM_006233022.5 → XP_006233084.1  2-Hydroxyacid oxidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K713, A0A8L2UQG3
      Related
      ENSRNOP00000071695.2
      Conserved Domains (2) summary
      cd02809
      Location:18 → 359
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
      pfam01070
      Location:25 → 363
      FMN_dh; FMN-dependent dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07523.2 GenPept UniProtKB/Swiss-Prot:Q07523

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