Anapc4 anaphase promoting complex subunit 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anapc4provided by RGD
Official Full Name: anaphase promoting complex subunit 4provided by RGD
Primary source: RGD:1306572
See related: Ensembl:ENSRNOG00000004130 AllianceGenome:RGD:1306572
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 183.6), Lung (RPKM 159.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (62338798..62370572, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (58125995..58159253, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (60471962..60503803, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Rat122 (e-PCR), detects polymorphism
- UniSTS:226622

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info
is_active_in nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anaphase-promoting complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107220.1 → NP_001100690.1 anaphase-promoting complex subunit 4

See identical proteins and their annotated locations for NP_001100690.1

Status: PROVISIONAL

Source sequence(s)

CH473963

UniProtKB/TrEMBL

A0A8I5ZJP1, A6IJG7, D3ZUB7

Related

ENSRNOP00000006093.3, ENSRNOT00000006093.5

Conserved Domains (3) summary

sd00039
Location:24 → 59

7WD40; WD40 repeat [structural motif]

pfam12894
Location:26 → 118

ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain

pfam12896
Location:232 → 431

ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4