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    NMUR1 neuromedin U receptor 1 [ Homo sapiens (human) ]

    Gene ID: 10316, updated on 6-Jun-2024

    Summary

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    Official Symbol
    NMUR1provided by HGNC
    Official Full Name
    neuromedin U receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4518
    See related
    Ensembl:ENSG00000171596 MIM:604153; AllianceGenome:HGNC:4518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FM3; FM-3; GPC-R; GPR66; NMU1R; (FM-3)
    Summary
    Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including activation of phospholipase C activity; chloride transport; and second-messenger-mediated signaling. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in fat (RPKM 2.5), lung (RPKM 1.6) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NMUR1 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (231518455..231530445, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232002894..232014900, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232387898..232395156, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 22, pseudogene Neighboring gene long intergenic non-protein coding RNA 471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232378431-232379240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232390957-232391458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232392564-232393091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232393092-232393618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232396108-232396842 Neighboring gene uncharacterized LOC105376787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232400385-232400886 Neighboring gene MPRA-validated peak4079 silencer Neighboring gene Sharpr-MPRA regulatory region 7070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17292 Neighboring gene ribosomal protein L21 pseudogene 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients. Tsukada A, et al. Int J Mol Sci, 2022 Sep 23. PMID 36232539, Free PMC Article
    2. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. Szekeres PG, et al. J Biol Chem, 2000 Jul 7. PMID 10811630
    3. Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. Tan CP, et al. Genomics, 1998 Sep 1. PMID 9782091
    4. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. Fujii R, et al. J Biol Chem, 2000 Jul 14. PMID 10783389
    5. Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Kojima M, et al. Biochem Biophys Res Commun, 2000 Sep 24. PMID 11027493

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients' nasal mucosa.
      Title: Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients' nasal mucosa.
    2. Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
      Title: Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
    3. Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients.
      Title: Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuromedin U binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuromedin U receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in smooth muscle contraction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neuromedin-U receptor 1
    Names
    G-protein coupled receptor 66
    G-protein coupled receptor FM-3
    NMU-R1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006056.5 → NP_006047.3  neuromedin-U receptor 1

      See identical proteins and their annotated locations for NP_006047.3

      Status: VALIDATED

      Source sequence(s)
      AC017104, AF272362, BP198644
      Consensus CDS
      CCDS2486.1
      UniProtKB/Swiss-Prot
      O43664, Q7LDP6, Q8NE20, Q9HB89
      Related
      ENSP00000305877.4, ENST00000305141.5
      Conserved Domains (1) summary
      pfam00001
      Location:77 → 356
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      231518455..231530445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712195.4 → XP_006712258.1  neuromedin-U receptor 1 isoform X3

      UniProtKB/TrEMBL
      B4DTH8
      Conserved Domains (1) summary
      pfam00001
      Location:77 → 249
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_006712196.4 → XP_006712259.1  neuromedin-U receptor 1 isoform X4

      UniProtKB/TrEMBL
      B4DTH8
      Conserved Domains (1) summary
      pfam00001
      Location:77 → 249
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_011510488.3 → XP_011508790.1  neuromedin-U receptor 1 isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:77 → 249
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. XM_011510489.3 → XP_011508791.1  neuromedin-U receptor 1 isoform X5

      UniProtKB/TrEMBL
      B4DTH8
      Conserved Domains (1) summary
      pfam00001
      Location:77 → 249
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    5. XM_011510487.4 → XP_011508789.1  neuromedin-U receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011508789.1

      UniProtKB/Swiss-Prot
      Q9HB89
      Conserved Domains (1) summary
      pfam00001
      Location:54 → 333
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      232002894..232014900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340177.1 → XP_054196152.1  neuromedin-U receptor 1 isoform X3

      UniProtKB/TrEMBL
      B4DTH8

    2. XM_054340178.1 → XP_054196153.1  neuromedin-U receptor 1 isoform X4

      UniProtKB/TrEMBL
      B4DTH8

    3. XM_054340176.1 → XP_054196151.1  neuromedin-U receptor 1 isoform X2

    4. XM_054340179.1 → XP_054196154.1  neuromedin-U receptor 1 isoform X5

      UniProtKB/TrEMBL
      B4DTH8

    5. XM_054340175.1 → XP_054196150.1  neuromedin-U receptor 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HB89.1 GenPept UniProtKB/Swiss-Prot:Q9HB89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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