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    Dnai4 dynein axonemal intermediate chain 4 [ Mus musculus (house mouse) ]

    Gene ID: 242584, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Dnai4provided by MGI
    Official Full Name
    dynein axonemal intermediate chain 4provided by MGI
    Primary source
    MGI:MGI:2385328
    See related
    Ensembl:ENSMUSG00000035126 AllianceGenome:MGI:2385328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr78
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in axonemal dynein complex assembly and cilium movement. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axoneme and motile cilium. Part of axonemal dynein complex. Is expressed in brain and olfactory epithelium. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 5.9), testis adult (RPKM 5.6) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnai4 in Genome Data Viewer
    Location:
    4 C6; 4 47.28 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102891954..102971524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103038065..103114299, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102737628-102737949 Neighboring gene MEIR1 treanscription regulator Neighboring gene STARR-seq mESC enhancer starr_10936 Neighboring gene solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 Neighboring gene RIKEN cDNA 4921539E11 gene Neighboring gene STARR-seq mESC enhancer starr_10938 Neighboring gene STARR-seq mESC enhancer starr_10939

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Zhang Y, et al. J Mol Cell Biol, 2019 May 1. PMID 30060180, Free PMC Article
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31722, MGC38950

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of axonemal dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of axonemal dynein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein axonemal intermediate chain 4
    Names
    WD repeat domain 78
    WD repeat-containing protein 78
    dynein intermediate chain 4, axonemal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425039.1 → NP_001411968.1  dynein axonemal intermediate chain 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844176

    2. NM_146254.5 → NP_666366.4  dynein axonemal intermediate chain 4 isoform 1

      See identical proteins and their annotated locations for NP_666366.4

      Status: VALIDATED

      Source sequence(s)
      AL844176
      Consensus CDS
      CCDS38824.3
      UniProtKB/Swiss-Prot
      E9PYY5, Q8C0I9, Q8K042, Q8K111
      Related
      ENSMUSP00000102481.4, ENSMUST00000106868.4
      Conserved Domains (2) summary
      COG2319
      Location:444 → 790
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:498 → 542
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_189044.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844176

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      102891954..102971524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164129.1 → XP_036020022.1  dynein axonemal intermediate chain 4 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:444 → 792
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:498 → 542
      7WD40; WD40 repeat [structural motif]

    2. XM_030253560.2 → XP_030109420.1  dynein axonemal intermediate chain 4 isoform X3

      Conserved Domains (2) summary
      COG2319
      Location:401 → 749
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:455 → 499
      7WD40; WD40 repeat [structural motif]

    3. XM_030253559.2 → XP_030109419.1  dynein axonemal intermediate chain 4 isoform X2

      Conserved Domains (2) summary
      COG2319
      Location:441 → 763
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:469 → 513
      7WD40; WD40 repeat [structural motif]

    4. XM_030253561.1 → XP_030109421.1  dynein axonemal intermediate chain 4 isoform X4

      Conserved Domains (2) summary
      COG2319
      Location:314 → 662
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:368 → 412
      7WD40; WD40 repeat [structural motif]

    5. XM_030253562.2 → XP_030109422.1  dynein axonemal intermediate chain 4 isoform X5

      Conserved Domains (2) summary
      COG2319
      Location:195 → 543
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:249 → 293
      7WD40; WD40 repeat [structural motif]

    6. XM_017320218.3 → XP_017175707.1  dynein axonemal intermediate chain 4 isoform X8

    7. XM_006503078.5 → XP_006503141.1  dynein axonemal intermediate chain 4 isoform X7

    8. XM_006503077.5 → XP_006503140.1  dynein axonemal intermediate chain 4 isoform X6

    RNA

    1. XR_004941896.1 RNA Sequence

    2. XR_376319.5 RNA Sequence

    3. XR_004941895.1 RNA Sequence

    4. XR_376318.4 RNA Sequence

      Related
      ENSMUST00000116316.10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PYY5.1 GenPept UniProtKB/Swiss-Prot:E9PYY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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