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    CORO7 coronin 7 [ Homo sapiens (human) ]

    Gene ID: 79585, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CORO7provided by HGNC
    Official Full Name
    coronin 7provided by HGNC
    Primary source
    HGNC:HGNC:26161
    See related
    Ensembl:ENSG00000262246 MIM:611668; AllianceGenome:HGNC:26161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRN7; POD1; 0610011B16Rik
    Summary
    This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
    Expression
    Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CORO7 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4354542..4416596, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4383717..4445792, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4404543..4466597, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4374751-4375535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4378569-4379569 Neighboring gene GLIS family zinc finger 2 Neighboring gene GLIS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4389543-4390289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4390290-4391035 Neighboring gene CORO7-PAM16 readthrough Neighboring gene MPRA-validated peak2471 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4397350-4397850 Neighboring gene presequence translocase associated motor 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4415328-4415828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4419155-4419654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4421231-4422056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4424664-4425443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4425537-4426318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4426319-4427098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4428659-4429440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4433428-4434269 Neighboring gene vasorin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4440665-4441216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4441217-4441770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4452006-4452742 Neighboring gene uncharacterized LOC124903635 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4499977-4500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4505719-4506689

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. Rybakin V, et al. Cell Mol Life Sci, 2008 Aug. PMID 18581049
    2. Implication of coronin 7 in body weight regulation in humans, mice and flies. Eriksson A, et al. BMC Neurosci, 2015 Mar 14. PMID 25887538, Free PMC Article
    3. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. Rybakin V, et al. FEBS Lett, 2004 Aug 27. PMID 15327992
    4. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. Rybakin V, et al. J Biol Chem, 2006 Oct 13. PMID 16905771
    5. CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway. Park J, et al. J Biol Chem, 2021 Jan-Jun. PMID 33162394, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function
      Title: Implication of coronin 7 in body weight regulation in humans, mice and flies.
    2. Results show that enforced targeting of Crn7 to TGN 9trans-Golgi network) bypasses the requirement of K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi trafficking.
      Title: K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.
    3. Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex.
      Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Sequential events of protein interaction and posttranslational modification result in the membrane targeting of Crn7.
      Title: Molecular mechanism underlying the association of Coronin-7 with Golgi membranes.
    6. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi
      Title: Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi.
    7. role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton
      Title: Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough CORO7-PAM16

    Readthrough gene: CORO7-PAM16, Included gene: PAM16

    Homology

    Clone Names

    • FLJ22021, FLJ44188

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coronin-7
    Names
    70 kDa WD repeat tumor rejection antigen homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052966.1 RefSeqGene

      Range
      5366..67420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201472.2 → NP_001188401.1  coronin-7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC012676, AK294045, BM671637
      Consensus CDS
      CCDS58417.1
      UniProtKB/TrEMBL
      B4DKU9
      Related
      ENSP00000440460.2, ENST00000537233.6
      Conserved Domains (4) summary
      pfam08953
      Location:5 → 60
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:790 → 834
      WD40_4; Type of WD40 repeat
      sd00039
      Location:486 → 522
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:528 → 686
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001201473.2 → NP_001188402.1  coronin-7 isoform 3

      See identical proteins and their annotated locations for NP_001188402.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons that result in a missing in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK296807, BM671637
      Consensus CDS
      CCDS55982.1
      UniProtKB/TrEMBL
      B4DKU9
      Related
      ENSP00000461702.1, ENST00000574025.5
      Conserved Domains (4) summary
      pfam08953
      Location:5 → 60
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:723 → 767
      WD40_4; Type of WD40 repeat
      sd00039
      Location:419 → 455
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:461 → 619
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001351729.2 → NP_001338658.1  coronin-7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AK094596, BM671637, DA944874
      UniProtKB/TrEMBL
      B3KSY4, B3KUH7
      Conserved Domains (2) summary
      sd00039
      Location:284 → 320
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:251 → 660
      WD40_4; Type of WD40 repeat

    4. NM_024535.5 → NP_078811.3  coronin-7 isoform 1

      See identical proteins and their annotated locations for NP_078811.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC117291, BM671637, DR155527
      Consensus CDS
      CCDS10513.1
      UniProtKB/Swiss-Prot
      B4DFD6, B4DL18, I3L416, P57737, Q17RK4
      UniProtKB/TrEMBL
      B4DKU9
      Related
      ENSP00000251166.4, ENST00000251166.9
      Conserved Domains (2) summary
      sd00039
      Location:81 → 124
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:471 → 880
      WD40_4; Type of WD40 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      4354542..4416596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187608.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      56867..118919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      4383717..4445792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57737.2 GenPept UniProtKB/Swiss-Prot:P57737

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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