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    mapre1a microtubule-associated protein, RP/EB family, member 1a [ Danio rerio (zebrafish) ]

    Gene ID: 334135, updated on 25-Apr-2024

    Summary

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    Official Symbol
    mapre1aprovided by ZNC
    Official Full Name
    microtubule-associated protein, RP/EB family, member 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6067
    See related
    Ensembl:ENSDARG00000042927 AllianceGenome:ZFIN:ZDB-GENE-030131-6067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MAPRE1; mapre1l; zgc:55428; zgc:77807; wu:fi33c06
    Summary
    Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mapre1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23381955..23388641)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23360716..23367402)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4-like a Neighboring gene DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a Neighboring gene si:dkey-16n15.3 Neighboring gene si:dkey-16n15.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Lin X, et al. Life (Basel), 2022 Sep 16. PMID 36143477, Free PMC Article
    2. Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs. Marchal GA, et al. Circ Res, 2021 Jul 23. PMID 34092082, Free PMC Article
    3. Developmental remodelling of non-CG methylation at satellite DNA repeats. Ross SE, et al. Nucleic Acids Res, 2020 Dec 16. PMID 33271598, Free PMC Article
    4. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
    5. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein RP/EB family member 1a
    Names
    microtubule-associated protein, RP/EB family, member 1, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282033.1 → NP_001268962.1  microtubule-associated protein RP/EB family member 1a isoform 2

      See identical proteins and their annotated locations for NP_001268962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BC065871, CV103612
      UniProtKB/TrEMBL
      A0A8M1P5E8, Q6P020
      Related
      ENSDARP00000068730.5, ENSDART00000074241.7
      Conserved Domains (2) summary
      pfam00307
      Location:16 → 114
      CH; Calponin homology (CH) domain
      pfam03271
      Location:203 → 240
      EB1; EB1-like C-terminal motif

    2. NM_199864.2 → NP_956158.2  microtubule-associated protein RP/EB family member 1a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BC065871, CV103612, EH547703
      UniProtKB/TrEMBL
      A0A8M1PDK9, B0S585, E7F5C5
      Related
      ENSDARP00000063009.4, ENSDART00000063010.6
      Conserved Domains (2) summary
      pfam00307
      Location:16 → 114
      CH; Calponin homology (CH) domain
      pfam03271
      Location:217 → 254
      EB1; EB1-like C-terminal motif

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23381955..23388641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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