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    Zfp777 zinc finger protein 777 [ Mus musculus (house mouse) ]

    Gene ID: 72306, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp777provided by MGI
    Official Full Name
    zinc finger protein 777provided by MGI
    Primary source
    MGI:MGI:1919556
    See related
    Ensembl:ENSMUSG00000071477 AllianceGenome:MGI:1919556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2500002G23Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; genitourinary system; retina; and tooth. Orthologous to human ZNF777 (zinc finger protein 777). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.7), ovary adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp777 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47994594..48026963, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48017660..48050004, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15786 Neighboring gene nuclear encoded tRNA cysteine 57 (anticodon GCA) Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15788 Neighboring gene zinc finger protein 746 Neighboring gene nuclear encoded tRNA cysteine 37 (anticodon GCA) Neighboring gene predicted gene, 30435 Neighboring gene predicted gene, 16630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 777

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081382.2 → NP_001074851.1  zinc finger protein 777 isoform 1

      See identical proteins and their annotated locations for NP_001074851.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC166290
      Consensus CDS
      CCDS39477.1
      UniProtKB/TrEMBL
      B9EKF4
      Related
      ENSMUSP00000110230.2, ENSMUST00000114583.8
      Conserved Domains (8) summary
      smart00349
      Location:328 → 388
      KRAB; krueppel associated box
      COG5048
      Location:694 → 880
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:750 → 770
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:723 → 740
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:748 → 770
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:328 → 367
      KRAB; KRAB box
      pfam13465
      Location:762 → 786
      zf-H2C2_2; Zinc-finger double domain
      pfam14353
      Location:691 → 740
      CpXC; CpXC protein

    2. NM_001347139.1 → NP_001334068.1  zinc finger protein 777 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC166290
      Consensus CDS
      CCDS85035.1
      UniProtKB/TrEMBL
      G5E8L5
      Conserved Domains (7) summary
      smart00349
      Location:284 → 344
      KRAB; krueppel associated box
      COG5048
      Location:650 → 836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706 → 726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679 → 696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557 → 579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2 → 180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198 → 254
      DUF3669; Zinc finger protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47994594..48026963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506675.4 → XP_006506738.2  zinc finger protein 777 isoform X3

      Conserved Domains (2) summary
      smart00349
      Location:470 → 530
      KRAB; krueppel associated box
      pfam12417
      Location:384 → 440
      DUF3669; Zinc finger protein

    2. XM_006506673.5 → XP_006506736.1  zinc finger protein 777 isoform X2

      See identical proteins and their annotated locations for XP_006506736.1

      UniProtKB/TrEMBL
      G5E8L5
      Related
      ENSMUSP00000093637.4, ENSMUST00000095944.10
      Conserved Domains (7) summary
      smart00349
      Location:284 → 344
      KRAB; krueppel associated box
      COG5048
      Location:650 → 836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706 → 726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679 → 696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557 → 579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2 → 180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198 → 254
      DUF3669; Zinc finger protein

    3. XM_011241478.4 → XP_011239780.1  zinc finger protein 777 isoform X2

      See identical proteins and their annotated locations for XP_011239780.1

      UniProtKB/TrEMBL
      G5E8L5
      Conserved Domains (7) summary
      smart00349
      Location:284 → 344
      KRAB; krueppel associated box
      COG5048
      Location:650 → 836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706 → 726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679 → 696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557 → 579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2 → 180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198 → 254
      DUF3669; Zinc finger protein

    4. XM_006506674.5 → XP_006506737.1  zinc finger protein 777 isoform X2

      See identical proteins and their annotated locations for XP_006506737.1

      UniProtKB/TrEMBL
      G5E8L5
      Conserved Domains (7) summary
      smart00349
      Location:284 → 344
      KRAB; krueppel associated box
      COG5048
      Location:650 → 836
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:706 → 726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:679 → 696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557 → 579
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:2 → 180
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:198 → 254
      DUF3669; Zinc finger protein

    5. XM_006506671.5 → XP_006506734.1  zinc finger protein 777 isoform X1

      Conserved Domains (7) summary
      smart00349
      Location:307 → 367
      KRAB; krueppel associated box
      COG5048
      Location:673 → 859
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:729 → 749
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:702 → 719
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:580 → 602
      zf-C2H2; Zinc finger, C2H2 type
      pfam03154
      Location:14 → 203
      Atrophin-1; Atrophin-1 family
      pfam12417
      Location:221 → 277
      DUF3669; Zinc finger protein

    RNA

    1. XR_003956255.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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