Fbxo7 F-box protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo7provided by MGI
Official Full Name: F-box protein 7provided by MGI
Primary source: MGI:MGI:1917004
See related: Ensembl:ENSMUSG00000001786 AllianceGenome:MGI:1917004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410015K21Rik; A230052G17Rik
Summary: Enables protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and negative regulation of lymphocyte differentiation. Located in mitochondrion and nucleus. Is expressed in dorsal root ganglion; gallbladder; liver; trigeminal ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 26.7), liver E14.5 (RPKM 23.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 41.91 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (85856313..85887737)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (86020449..86051873)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice.
Title: Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice.
FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
Title: FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Title: Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.
Title: Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.
Loss of Fbxo7 in myelinating glia led to axonal degeneration in the CNS and peripheral neuropathy.
Title: Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy.
The neuroprotective role of FBXO7 involves its suppression of the RPL23-MDM2-p53 axis that promotes cell death in dopaminergic midbrain neurons.
Title: Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway.
Fbxo7 hypomorphs were produced at a normal Mendelian ratio with a normal lifespan and no evidence of neurological symptoms. These data suggest that erythrocyte survival, T cell development and spermatogenesis are particularly sensitive to Fbxo7 gene dosage.
Title: FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.
Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development.
Title: Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.
Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function.
Title: Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice.
Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 expression.
Title: Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI117679 (e-PCR)
- UniSTS:160014

AW260462 (e-PCR)
- UniSTS:180092

RH127130 (e-PCR)
- UniSTS:208584

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of locomotion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Lewy body core	ISO Inferred from Sequence Orthology more info
located_in Lewy body corona	ISO Inferred from Sequence Orthology more info
located_in Lewy neurite	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in classical Lewy body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glial cytoplasmic inclusion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310745.1 → NP_001297674.1 F-box only protein 7 isoform 2

See identical proteins and their annotated locations for NP_001297674.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC122919, AK010499, AK150190

Consensus CDS

CCDS78875.1

UniProtKB/TrEMBL

Q3UD93

Related

ENSMUSP00000113222.2, ENSMUST00000120344.8

Conserved Domains (3) summary

pfam06881
Location:293 → 335

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

pfam11566
Location:110 → 243

PI31_Prot_N; PI31 proteasome regulator N-terminal

pfam12937
Location:257 → 300

F-box-like; F-box-like
NM_001347151.1 → NP_001334080.1 F-box only protein 7 isoform 3

Status: VALIDATED

Source sequence(s)

AC122919, AI447461, AK082146, AK147716, AK147907, AK150626

Consensus CDS

CCDS83740.1

UniProtKB/TrEMBL

Q3UGI9

Related

ENSMUSP00000113263.2, ENSMUST00000117597.2

Conserved Domains (3) summary

pfam06881
Location:291 → 333

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

pfam11566
Location:112 → 237

PI31_Prot_N; PI31 proteasome regulator N-terminal

pfam12937
Location:255 → 296

F-box-like
NM_153195.2 → NP_694875.2 F-box only protein 7 isoform 1

See identical proteins and their annotated locations for NP_694875.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK151025, CD563204

Consensus CDS

CCDS24095.1

UniProtKB/Swiss-Prot

Q3U7U3, Q3UBC1, Q8K0A5

Related

ENSMUSP00000120840.2, ENSMUST00000130320.8

Conserved Domains (3) summary

pfam06881
Location:372 → 414

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

pfam11566
Location:189 → 322

PI31_Prot_N; PI31 proteasome regulator N-terminal

pfam12937
Location:336 → 379

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

85856313..85887737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314077.2 → XP_017169566.1 F-box only protein 7 isoform X1

Conserved Domains (4) summary

pfam06881
Location:340 → 382

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

pfam11566
Location:193 → 292

PI31_Prot_N; PI31 proteasome regulator N-terminal

pfam12937
Location:304 → 345

F-box-like

cl28922
Location:1 → 77

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_011243556.3 → XP_011241858.1 F-box only protein 7 isoform X2

See identical proteins and their annotated locations for XP_011241858.1

Conserved Domains (3) summary

pfam06881
Location:234 → 276

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

pfam11566
Location:55 → 180

PI31_Prot_N; PI31 proteasome regulator N-terminal

pfam12937
Location:198 → 239

F-box-like