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    Rhot2 ras homolog family member T2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287156, updated on 11-Apr-2024

    Summary

    Official Symbol
    Rhot2provided by RGD
    Official Full Name
    ras homolog family member T2provided by RGD
    Primary source
    RGD:727970
    See related
    Ensembl:ENSRNOG00000019930 AllianceGenome:RGD:727970
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Miro2
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; and regulation of mitochondrion organization. Predicted to be located in mitochondrion. Predicted to be integral component of mitochondrial outer membrane. Orthologous to human RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 137.3), Kidney (RPKM 132.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rhot2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15363467..15369263, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14858954..14864751, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15205943..15211739, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 8 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene rhomboid like 1 Neighboring gene WD repeat domain 90 Neighboring gene MAPK regulated co-repressor interacting protein 2 Neighboring gene methyltransferase like 26 Neighboring gene transfer RNA glycine (anticodon CCC) 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial outer membrane permeabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial outer membrane permeabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial Rho GTPase 2
    Names
    MIRO-2
    ras homolog gene family, member T2
    NP_861544.1
    XP_017452558.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181823.1NP_861544.1  mitochondrial Rho GTPase 2

      See identical proteins and their annotated locations for NP_861544.1

      Status: PROVISIONAL

      Source sequence(s)
      AY303973
      UniProtKB/Swiss-Prot
      Q7TSA0
      UniProtKB/TrEMBL
      A6HD65
      Related
      ENSRNOP00000027083.3, ENSRNOT00000027083.6
      Conserved Domains (6) summary
      smart00174
      Location:7169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:414593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:422534
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341408
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221301
      EF_assoc_2; EF hand associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15363467..15369263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597069.2XP_017452558.1  mitochondrial Rho GTPase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSA0
      UniProtKB/TrEMBL
      A6HD65
      Conserved Domains (6) summary
      smart00174
      Location:7169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:414593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:422534
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341408
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221301
      EF_assoc_2; EF hand associated