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    Zbtb4 zinc finger and BTB domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287441, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zbtb4provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 4provided by RGD
    Primary source
    RGD:1307184
    See related
    Ensembl:ENSRNOG00000014689 AllianceGenome:RGD:1307184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; methyl-CpNpG binding activity; and sequence-specific DNA binding activity. Predicted to be involved in cellular response to DNA damage stimulus and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Orthologous to human ZBTB4 (zinc finger and BTB domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 186.3), Brain (RPKM 148.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb4 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54979421..55000215)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54480698..54501492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56367586..56388296)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 19 Neighboring gene RNA polymerase II subunit A Neighboring gene solute carrier family 35, member G3 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene fibroblast growth factor 11 Neighboring gene transmembrane protein 102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequence-specific recognition of methylated DNA by human zinc-finger proteins. Sasai N, et al. Nucleic Acids Res, 2010 Aug. PMID 20403812, Free PMC Article
    2. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. Yamada D, et al. Oncogene, 2009 Jul 9. PMID 19448668
    3. A family of human zinc finger proteins that bind methylated DNA and repress transcription. Filion GJ, et al. Mol Cell Biol, 2006 Jan. PMID 16354688, Free PMC Article
    4. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA, et al. Epigenetics, 2013 Feb. PMID 23324617, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpNpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304352.1 → NP_001291281.1  zinc finger and BTB domain-containing protein 4

      See identical proteins and their annotated locations for NP_001291281.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D4A8X0
      Related
      ENSRNOP00000019687.4, ENSRNOT00000019687.7
      Conserved Domains (6) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam00096
      Location:736 → 758
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:341 → 364
      zf-C2H2_4; C2H2-type zinc finger
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54979421..55000215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246844.4 → XP_006246906.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006246906.1

      UniProtKB/Swiss-Prot
      D4A8X0
      Conserved Domains (6) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam00096
      Location:736 → 758
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:341 → 364
      zf-C2H2_4; C2H2-type zinc finger
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    2. XM_039085459.2 → XP_038941387.1  zinc finger and BTB domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D4A8X0
      Conserved Domains (6) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam00096
      Location:736 → 758
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:341 → 364
      zf-C2H2_4; C2H2-type zinc finger
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A8X0.1 GenPept UniProtKB/Swiss-Prot:D4A8X0

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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