F2RL3 F2R like thrombin or trypsin receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: F2RL3provided by HGNC
Official Full Name: F2R like thrombin or trypsin receptor 3provided by HGNC
Primary source: HGNC:HGNC:3540
See related: Ensembl:ENSG00000127533 MIM:602779; AllianceGenome:HGNC:3540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAR4
Summary: This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
Expression: Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (16888999..16892606)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (17023836..17027443)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (16999810..17003417)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes.
Title: The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes.
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.
Title: The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.
Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study.
Title: Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study.
An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
Title: An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population.
Title: The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population.
Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice.
Title: Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice.
Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function.
Title: Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function.
Disruption of the biological activity of protease-activated receptors2/4 in adults rather than children in SARS CoV-2 virus-mediated mortality in COVID-19 infection.
Title: Disruption of the biological activity of protease-activated receptors2/4 in adults rather than children in SARS CoV-2 virus-mediated mortality in COVID-19 infection.
PAR-4/Ca(2+)-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes.
Title: PAR-4/Ca(2+)-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes.
Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4).
Title: Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4).

Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC98608P2 (e-PCR)
- UniSTS:273677

PMC22903P1 (e-PCR)
- UniSTS:272167

L17705 (e-PCR)
- UniSTS:66091

PMC156606P1 (e-PCR)
- UniSTS:271408

NoName (e-PCR)
- UniSTS:481901

GDB:313783 (e-PCR)
- UniSTS:13512

PMC22580P1 (e-PCR)
- UniSTS:272119

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables thrombin-activated receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet activation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet activation	TAS Traceable Author Statement more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in platelet dense granule organization	IC Inferred by Curator more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: proteinase-activated receptor 4

Names: F2R like thrombin/trypsin receptor 3; PAR-4; coagulation factor II (thrombin) receptor-like 3; protease-activated receptor-4; thrombin receptor-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.