Tmprss12 transmembrane (C-terminal) protease, serine 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss12provided by MGI
Official Full Name: transmembrane (C-terminal) protease, serine 12provided by MGI
Primary source: MGI:MGI:1922252
See related: Ensembl:ENSMUSG00000045631 AllianceGenome:MGI:1922252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930478A21Rik
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within binding activity of sperm to zona pellucida and protein processing. Located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 14.1) See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.24 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100178743..100190943)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100280837..100293056)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmprss12 is required for sperm motility and uterotubal junction migration in micedagger.
Title: Tmprss12 is required for sperm motility and uterotubal junction migration in mice†.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493073

NoName (e-PCR)
- UniSTS:487973

NoName (e-PCR)
- UniSTS:494211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418781.1 → NP_001405710.1 transmembrane protease serine 12 isoform 2

Status: VALIDATED

Source sequence(s)

AC124479
NM_183109.4 → NP_898932.2 transmembrane protease serine 12 isoform 1 precursor

See identical proteins and their annotated locations for NP_898932.2

Status: VALIDATED

Source sequence(s)

AC124479

Consensus CDS

CCDS49732.1

UniProtKB/Swiss-Prot

Q3V0Q7

Related

ENSMUSP00000093914.5, ENSMUST00000096200.6

Conserved Domains (2) summary

smart00020
Location:65 → 300

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:66 → 300

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...