Akr1c12 aldo-keto reductase family 1, member C12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1c12provided by MGI
Official Full Name: aldo-keto reductase family 1, member C12provided by MGI
Primary source: MGI:MGI:1351661
See related: Ensembl:ENSMUSG00000021211 AllianceGenome:MGI:1351661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Akra
Summary: Predicted to enable several functions, including oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid metabolic process. Predicted to act upstream of or within xenobiotic metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in gut and male reproductive system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 14.9), large intestine adult (RPKM 13.7) and 11 other tissues See more
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Genomic context

Location:: 13 A1; 13 2.39 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (4318171..4329398, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (4268172..4279399, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

AI266976 (e-PCR)
- UniSTS:180494

Akr1c13 (e-PCR), detects polymorphism
- UniSTS:256598

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables chlordecone reductase activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables steroid dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aldo-keto reductase family 1, member C12

Names: aldo-keto reductase a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013777.2 → NP_038805.2 aldo-keto reductase family 1, member C12

See identical proteins and their annotated locations for NP_038805.2

Status: VALIDATED

Source sequence(s)

AK007716, BY148924, BY583815

Consensus CDS

CCDS26222.1

UniProtKB/TrEMBL

Q91X42, Q9JLI0

Related

ENSMUSP00000021632.4, ENSMUST00000021632.5

Conserved Domains (2) summary

COG0656
Location:7 → 307

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:6 → 297

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]