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    Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 [ Mus musculus (house mouse) ]

    Gene ID: 394433, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ugt1a5provided by MGI
    Official Full Name
    UDP glucuronosyltransferase 1 family, polypeptide A5provided by MGI
    Primary source
    MGI:MGI:3032634
    See related
    Ensembl:ENSMUSG00000089943 AllianceGenome:MGI:3032634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme binding activity; glucuronosyltransferase activity; and protein dimerization activity. Predicted to be involved in flavonoid glucuronidation; vitamin D3 metabolic process; and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum. Orthologous to human UGT1A4 (UDP glucuronosyltransferase family 1 member A4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 235.0), liver adult (RPKM 156.2) and 9 other tissues See more
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    Genomic context

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    See Ugt1a5 in Genome Data Viewer
    Location:
    1 D; 1 44.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88093734..88147724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88166012..88220002)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene 15371 Neighboring gene predicted gene 15368 Neighboring gene predicted gene 15376 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel system for expressing recombinant proteins over a wide temperature range from 4 to 35 degrees C. Nakashima N, et al. Biotechnol Bioeng, 2004 Apr 20. PMID 15052633
    2. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP glucuronosyltransferase 1 family, polypeptide A5
    Names
    UDP glycosyltransferase 1 family, polypeptide A5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201643.2 → NP_964005.2  UDP glucuronosyltransferase 1 family, polypeptide A5 precursor

      See identical proteins and their annotated locations for NP_964005.2

      Status: VALIDATED

      Source sequence(s)
      AC087780, AC087801, AY227196
      Consensus CDS
      CCDS35659.1
      UniProtKB/TrEMBL
      B2RT14, Q6XL48
      Related
      ENSMUSP00000095263.5, ENSMUST00000097659.5
      Conserved Domains (2) summary
      PHA03392
      Location:257 → 501
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:26 → 520
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88093734..88147724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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