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    Cep152 centrosomal protein 152 [ Mus musculus (house mouse) ]

    Gene ID: 99100, updated on 9-May-2024

    Summary

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    Official Symbol
    Cep152provided by MGI
    Official Full Name
    centrosomal protein 152provided by MGI
    Primary source
    MGI:MGI:2139083
    See related
    Ensembl:ENSMUSG00000068394 AllianceGenome:MGI:2139083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0912
    Summary
    Predicted to enable protein kinase binding activity. Involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Located in centrosome and deuterosome. Is expressed in brain; pharynx epithelium; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.4), liver E14 (RPKM 3.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep152 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125391784..125467081, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125549864..125625174, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:125073047-125073348 Neighboring gene STARR-seq mESC enhancer starr_05587 Neighboring gene STARR-seq mESC enhancer starr_05588 Neighboring gene deoxyuridine triphosphatase Neighboring gene fibrillin 1 Neighboring gene STARR-seq mESC enhancer starr_05589 Neighboring gene STARR-positive B cell enhancer ABC_E1254 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9530 Neighboring gene SHC (Src homology 2 domain containing) family, member 4 Neighboring gene predicted gene, 35231 Neighboring gene EP300 interacting inhibitor of differentiation 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Guernsey DL, et al. Am J Hum Genet, 2010 Jul 9. PMID 20598275, Free PMC Article
    2. Cep63 and cep152 cooperate to ensure centriole duplication. Brown NJ, et al. PLoS One, 2013. PMID 23936128, Free PMC Article
    3. Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development. Hamada N, et al. Dev Neurosci, 2022. PMID 35259752
    4. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
    5. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Bazzi H, et al. Proc Natl Acad Sci U S A, 2014 Apr 15. PMID 24706806, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in deuterosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in procentriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 152 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081091.1 → NP_001074560.1  centrosomal protein of 152 kDa

      See identical proteins and their annotated locations for NP_001074560.1

      Status: VALIDATED

      Source sequence(s)
      AL928930, AL929166, BX321866
      Consensus CDS
      CCDS38229.1
      UniProtKB/Swiss-Prot
      A2AUM9, Q69ZV8, Q8R0X1
      Related
      ENSMUSP00000087208.3, ENSMUST00000089776.3
      Conserved Domains (5) summary
      COG1390
      Location:1298 → 1422
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam07106
      Location:281 → 386
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      cd16269
      Location:794 → 803
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:610 → 803
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:977 → 1085
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125391784..125467081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239870.3 → XP_011238172.1  centrosomal protein of 152 kDa isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:620 → 1272
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:238 → 812
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_036162757.1 → XP_036018650.1  centrosomal protein of 152 kDa isoform X6

      Conserved Domains (2) summary
      PTZ00121
      Location:565 → 1074
      PTZ00121; MAEBL; Provisional
      COG0419
      Location:276 → 803
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    3. XM_036162756.1 → XP_036018649.1  centrosomal protein of 152 kDa isoform X3

      Conserved Domains (2) summary
      PTZ00121
      Location:619 → 1271
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:235 → 811
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006500474.5 → XP_006500537.1  centrosomal protein of 152 kDa isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:619 → 1271
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:237 → 811
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_017319354.3 → XP_017174843.1  centrosomal protein of 152 kDa isoform X5

      Conserved Domains (2) summary
      PTZ00121
      Location:566 → 1075
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:238 → 812
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_011239871.3 → XP_011238173.1  centrosomal protein of 152 kDa isoform X4

      Conserved Domains (2) summary
      PTZ00121
      Location:566 → 1075
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:238 → 812
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_036162760.1 → XP_036018653.1  centrosomal protein of 152 kDa isoform X9

      Conserved Domains (2) summary
      PTZ00121
      Location:358 → 845
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:6 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_036162758.1 → XP_036018651.1  centrosomal protein of 152 kDa isoform X8

      Conserved Domains (2) summary
      PTZ00121
      Location:390 → 1042
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:6 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_006500473.4 → XP_006500536.1  centrosomal protein of 152 kDa isoform X7

      Conserved Domains (2) summary
      PTZ00121
      Location:390 → 1042
      PTZ00121; MAEBL; Provisional
      TIGR02168
      Location:8 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_001783212.3 RNA Sequence

    2. XR_001783214.3 RNA Sequence

    3. XR_001783213.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AUM9.1 GenPept UniProtKB/Swiss-Prot:A2AUM9

    Gene LinkOut

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