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    ogt.2 O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 652952, updated on 25-Apr-2024

    Summary

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    Official Symbol
    ogt.2provided by ZNC
    Official Full Name
    O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051128-1
    See related
    Ensembl:ENSDARG00000099455 AllianceGenome:ZFIN:ZDB-GENE-051128-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ogtb; ogtl
    Summary
    Enables protein N-acetylglucosaminyltransferase activity. Acts upstream of or within protein phosphopantetheinylation. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ogt.2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (14687721..14705751, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (14382158..14405227, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene centrin, EF-hand protein, 2 Neighboring gene germ cell nuclear acidic peptidase Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 Neighboring gene FH2 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis. Sohn KC, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16188232
    2. Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. Lee Y, et al. FASEB J, 2020 Jan. PMID 31914627
    3. O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. Webster DM, et al. BMC Dev Biol, 2009 Apr 21. PMID 19383152, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Names
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 2
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) like
    XP_001921543.2
    XP_005157261.1
    XP_021336805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386798.1 → NP_001373727.1  O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX323828, CR753843
      Conserved Domains (3) summary
      TIGR02917
      Location:22 → 465
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:327 → 355
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:476 → 1014
      Glyco_transf_41; Glycosyl transferase family 41

    2. NM_001386799.1 → NP_001373728.1  O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX323828, CR753843
      Conserved Domains (3) summary
      TIGR02917
      Location:23 → 455
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:317 → 345
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:466 → 1004
      Glyco_transf_41; Glycosyl transferase family 41

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      14687721..14705751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001921508.4 → XP_001921543.2  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A0A0R4IVJ0, A0A8M1QLF2
      Related
      ENSDARP00000138724.1, ENSDART00000168092.2
      Conserved Domains (7) summary
      COG0457
      Location:226 → 497
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:383 → 411
      TPR; TPR repeat [structural motif]
      cd15832
      Location:277 → 310
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:145 → 178
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:145 → 210
      TPR_11; TPR repeat
      pfam13844
      Location:612 → 1078
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:277 → 486
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    2. XM_021481130.1 → XP_021336805.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8M9QPC9
      Conserved Domains (3) summary
      sd00006
      Location:151 → 179
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:380 → 845
      Glyco_transf_41; Glycosyl transferase family 41
      cl26002
      Location:6 → 289
      TPR_11; TPR repeat

    3. XM_005157204.3 → XP_005157261.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2

      UniProtKB/TrEMBL
      A0A8M2B3B2
      Related
      ENSDARP00000136590.2, ENSDART00000157392.2
      Conserved Domains (7) summary
      COG0457
      Location:216 → 487
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:373 → 401
      TPR; TPR repeat [structural motif]
      cd15832
      Location:267 → 300
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:135 → 168
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:135 → 200
      TPR_11; TPR repeat
      pfam13844
      Location:602 → 1068
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:267 → 476
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    Nucleotide Protein Strain
    Heading Accession and Version

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