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    eif2a eukaryotic translation initiation factor 2A [ Danio rerio (zebrafish) ]

    Gene ID: 573991, updated on 27-Mar-2024

    Summary

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    Official Symbol
    eif2aprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050626-52
    See related
    Ensembl:ENSDARG00000101061 AllianceGenome:ZFIN:ZDB-GENE-050626-52
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7145971; zgc:110460
    Summary
    Predicted to enable RNA binding activity and ribosome binding activity. Predicted to be involved in regulation of translation. Predicted to act upstream of or within translational initiation. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See eif2a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (3552641..3571568, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (3455556..3474483, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100538302 Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Heat resilience in embryonic zebrafish revealed using an in vivo stress granule reporter. Wang R, et al. J Cell Sci, 2019 Oct 18. PMID 31558681, Free PMC Article
    2. A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis. Liu ZY, et al. Gene, 2013 Sep 15. PMID 23742890
    3. Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. Qin J, et al. Environ Pollut, 2020 Aug. PMID 32283406
    4. Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Mi X, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Oct 1. PMID 32446740
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
      Title: A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2A
    Names
    eIF-2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025170.2 → NP_001020341.1  eukaryotic translation initiation factor 2A

      See identical proteins and their annotated locations for NP_001020341.1

      Status: PROVISIONAL

      Source sequence(s)
      BC096815
      UniProtKB/Swiss-Prot
      Q4QRJ7
      UniProtKB/TrEMBL
      B2GSC5
      Related
      ENSDARP00000132954.1, ENSDART00000168842.2
      Conserved Domains (2) summary
      pfam08662
      Location:215 → 410
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:275 → 320
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      3552641..3571568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QRJ7.1 GenPept UniProtKB/Swiss-Prot:Q4QRJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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