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    NORAD non-coding RNA activated by DNA damage [ Homo sapiens (human) ]

    Gene ID: 647979, updated on 23-Mar-2024

    Summary

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    Official Symbol
    NORADprovided by HGNC
    Official Full Name
    non-coding RNA activated by DNA damageprovided by HGNC
    Primary source
    HGNC:HGNC:44311
    See related
    Ensembl:ENSG00000260032 MIM:617037; AllianceGenome:HGNC:44311
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00657
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    Genomic context

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    See NORAD in Genome Data Viewer
    Location:
    20q11.23
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (36045618..36050960, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37766598..37771940, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34633540..34638882, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17802 Neighboring gene uncharacterized LOC124904982 Neighboring gene SCAN domain containing 1 Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:34637879-34639078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17803 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12866 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34679298-34680250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34681205-34682156 Neighboring gene high mobility group box 3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34683285-34683786 Neighboring gene NANOG hESC enhancer GRCh37_chr20:34685650-34686158 Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34700699-34701198 Neighboring gene uncharacterized LOC124904977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. m6A Modification Mediates Exosomal LINC00657 to Trigger Breast Cancer Progression Via Inducing Macrophage M2 Polarization. Chen J, et al. Clin Breast Cancer, 2023 Jul. PMID 37198028
    2. Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis. Liu D, et al. Folia Neuropathol, 2023. PMID 37114966
    3. Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension. Liang Z, et al. Ginekol Pol, 2023. PMID 35894504
    4. Diagnostic value of lncRNA NORAD in pulmonary tuberculosis and its regulatory role in Mycobacterium tuberculosis infection of macrophages. Sun W, et al. Microbiol Immunol, 2022 Sep. PMID 35568971
    5. Upregulated NORAD is implicated in apoptosis, inflammation, and oxidative stress in ulcerative colitis through the nuclear factor-κappaB signaling. Lei N, et al. Eur J Gastroenterol Hepatol, 2022 Jun 1. PMID 35412486

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis.
      Title: Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis.
    2. Clinical significance of long non-coding RNA NORAD in rheumatoid arthritis.
      Title: Clinical significance of long non-coding RNA NORAD in rheumatoid arthritis.
    3. "Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study".
      Title: "Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study".
    4. LncRNA NORAD defects deteriorate the formation of age-related macular degeneration.
      Title: LncRNA NORAD defects deteriorate the formation of age-related macular degeneration.
    5. Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension.
      Title: Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension.
    6. m6A Modification Mediates Exosomal LINC00657 to Trigger Breast Cancer Progression Via Inducing Macrophage M2 Polarization.
      Title: m6A Modification Mediates Exosomal LINC00657 to Trigger Breast Cancer Progression Via Inducing Macrophage M2 Polarization.
    7. lncRNA NORAD, soluble ICAM1 and their correlations may be related to the regulation of the tumor immune microenvironment in laryngeal squamous cell carcinoma (LSCC).
      Title: lncRNA NORAD, soluble ICAM1 and their correlations may be related to the regulation of the tumor immune microenvironment in laryngeal squamous cell carcinoma (LSCC).
    8. Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis.
      Title: Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis.
    9. Long Noncoding RNA NORAD Promotes Fracture Healing through Interacting with Osteoblast Differentiation via Targeting miR-26a.
      Title: Long Noncoding RNA NORAD Promotes Fracture Healing through Interacting with Osteoblast Differentiation via Targeting miR-26a.
    10. LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
      Title: LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 657

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein sequestering activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability TAS
    Traceable Author Statement
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027451.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI619767, AK090641, AL035420, BC011592
      Related
      ENST00000565493.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      36045618..36050960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      37766598..37771940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials