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    Dync1i2 dynein cytoplasmic 1 intermediate chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 13427, updated on 12-May-2024

    Summary

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    Official Symbol
    Dync1i2provided by MGI
    Official Full Name
    dynein cytoplasmic 1 intermediate chain 2provided by MGI
    Primary source
    MGI:MGI:107750
    See related
    Ensembl:ENSMUSG00000027012 AllianceGenome:MGI:107750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dncic2; 3110079H08Rik
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in negative regulation of neuron projection development and transport along microtubule. Part of outer dynein arm. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb bud; and nose. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 64.5), CNS E14 (RPKM 54.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dync1i2 in Genome Data Viewer
    Location:
    2 C2; 2 42.38 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71041999..71093647)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71211676..71263303)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome b reductase 1 Neighboring gene STARR-seq mESC enhancer starr_04772 Neighboring gene predicted gene, 39576 Neighboring gene STARR-seq mESC enhancer starr_04777 Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71198352-71198535 Neighboring gene STARR-seq mESC enhancer starr_04786 Neighboring gene STARR-seq mESC enhancer starr_04790 Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. Kuta A, et al. PLoS One, 2010 Jul 21. PMID 20657784, Free PMC Article
    2. Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis. Pyr dit Ruys S, et al. Biochim Biophys Acta, 2009 Nov. PMID 19744529
    3. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. Crackower MA, et al. Genomics, 1999 Feb 1. PMID 10049579
    4. ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. Shah M, et al. J Cell Biol, 2013 Jul 8. PMID 23836931, Free PMC Article
    5. Animal models of lysosomal disease: an overview. Suzuki K, et al. J Inherit Metab Dis, 1998 Aug. PMID 9728334

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SQSTM1 is required for proper dynein motility and trafficking along microtubules.
      Title: Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.
    2. Study found Dync1i2 has 11 isoforms: six including exon 1a, five including exon 1b; isoforms with the same exon content other than exon 1a and 1b have similar but not identical expression patterns.
      Title: Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer dynein arm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 1 intermediate chain 2
    Names
    DH IC-2
    dynein intermediate chain 2, cytosolic
    dynein, cytoplasmic, intermediate chain 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198872.1 → NP_001185801.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

      See identical proteins and their annotated locations for NP_001185801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1; also called 1a.D) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 6 encode the same protein.
      Source sequence(s)
      BQ174310, BY065048, GU992208
      UniProtKB/TrEMBL
      D6Q0F5, Q3UDA2
      Conserved Domains (4) summary
      COG2319
      Location:346 → 616
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:152 → 180
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:356 → 394
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:397 → 622
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001198873.1 → NP_001185802.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

      See identical proteins and their annotated locations for NP_001185802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2; also called 1a.E) uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 2 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
      Source sequence(s)
      BQ174310, BY065048, GU992209
      UniProtKB/TrEMBL
      D6Q0F6, Q3UDA2
      Conserved Domains (4) summary
      COG2319
      Location:341 → 611
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:147 → 175
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:351 → 389
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:392 → 617
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001198874.1 → NP_001185803.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

      See identical proteins and their annotated locations for NP_001185803.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3; also called 1a.B) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 3 encodes a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AK141837, BQ174310, BY065048
      Consensus CDS
      CCDS57175.1
      UniProtKB/TrEMBL
      Q3TPJ8, Q3UDA2
      Related
      ENSMUSP00000107770.2, ENSMUST00000112142.8
      Conserved Domains (3) summary
      COG2319
      Location:323 → 593
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:333 → 371
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:129 → 157
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    4. NM_001198875.1 → NP_001185804.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

      See identical proteins and their annotated locations for NP_001185804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4; also called 1a.F) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 4 encodes a shorter isoform (4), compared to isoform 1.
      Source sequence(s)
      BQ174310, BY065048, GU992210
      UniProtKB/TrEMBL
      D6Q0F7, Q3UDA2
      Conserved Domains (3) summary
      COG2319
      Location:309 → 579
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:319 → 357
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:115 → 143
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    5. NM_001198876.1 → NP_001185805.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

      See identical proteins and their annotated locations for NP_001185805.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5; also called 1a.C) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 5 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
      Source sequence(s)
      AK164437, BQ174310, BY065048
      Consensus CDS
      CCDS16112.1
      UniProtKB/Swiss-Prot
      O88487, Q3TGH7
      UniProtKB/TrEMBL
      A2BFF7, Q3UDA2
      Related
      ENSMUSP00000107766.2, ENSMUST00000112138.8
      Conserved Domains (4) summary
      COG2319
      Location:303 → 573
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:109 → 137
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:313 → 351
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:253 → 572
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. NM_001198877.1 → NP_001185806.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

      See identical proteins and their annotated locations for NP_001185806.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6; also called 1b.D) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 6 encode the same protein (isoform 1).
      Source sequence(s)
      AK168730, BQ174310, BY226221, GU992211
      UniProtKB/TrEMBL
      D6Q0F5, Q3UDA2
      Conserved Domains (4) summary
      COG2319
      Location:346 → 616
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:152 → 180
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:356 → 394
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:397 → 622
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. NM_001198878.1 → NP_001185807.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

      See identical proteins and their annotated locations for NP_001185807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7; also called 1b.E) differs in the 5' UTR and uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 7 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
      Source sequence(s)
      AK164437, BQ174310, BY226221, GU992212
      UniProtKB/TrEMBL
      D6Q0F6, Q3UDA2
      Conserved Domains (4) summary
      COG2319
      Location:341 → 611
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:147 → 175
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:351 → 389
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:392 → 617
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. NM_001347173.1 → NP_001334102.1  cytoplasmic dynein 1 intermediate chain 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      BX284624, BX544878
      Consensus CDS
      CCDS84536.1
      UniProtKB/TrEMBL
      A2BFF9, Q3UDA2
      Related
      ENSMUSP00000107772.3, ENSMUST00000112144.9
      Conserved Domains (3) summary
      COG2319
      Location:329 → 599
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:339 → 377
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:135 → 163
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    9. NM_010064.4 → NP_034194.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

      See identical proteins and their annotated locations for NP_034194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8; also called 1b.C) differs in the 5' UTR and lacks multiple exons in the 5' coding region, compared to variant 1. Variant 8 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
      Source sequence(s)
      AK168730, BQ174310, BY226221, GU992210
      Consensus CDS
      CCDS16112.1
      UniProtKB/Swiss-Prot
      O88487, Q3TGH7
      UniProtKB/TrEMBL
      A2BFF7, Q3UDA2
      Related
      ENSMUSP00000080410.6, ENSMUST00000081710.12
      Conserved Domains (4) summary
      COG2319
      Location:303 → 573
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:109 → 137
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:313 → 351
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:253 → 572
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      71041999..71093647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315319.3 → XP_017170808.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

      UniProtKB/TrEMBL
      A2BFF9, Q3UDA2
      Related
      ENSMUSP00000107768.2, ENSMUST00000112140.8
      Conserved Domains (3) summary
      COG2319
      Location:329 → 599
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:339 → 377
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:135 → 163
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    2. XM_017315326.3 → XP_017170815.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

      UniProtKB/TrEMBL
      A2BFF8, Q3UDA2
      Related
      ENSMUSP00000107767.2, ENSMUST00000112139.8
      Conserved Domains (3) summary
      COG2319
      Location:303 → 573
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:313 → 351
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:109 → 137
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    3. XM_017315324.3 → XP_017170813.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

      UniProtKB/TrEMBL
      Q3UDA2
      Conserved Domains (3) summary
      COG2319
      Location:323 → 593
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:333 → 371
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:129 → 157
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    4. XM_006498678.4 → XP_006498741.1  cytoplasmic dynein 1 intermediate chain 2 isoform X5

      See identical proteins and their annotated locations for XP_006498741.1

      UniProtKB/TrEMBL
      D6Q0F7, Q3UDA2
      Conserved Domains (3) summary
      COG2319
      Location:309 → 579
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:319 → 357
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:115 → 143
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    5. XM_006498677.3 → XP_006498740.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

      See identical proteins and their annotated locations for XP_006498740.1

      UniProtKB/TrEMBL
      Q3TPJ8, Q3UDA2
      Related
      ENSMUSP00000097605.4, ENSMUST00000100028.10
      Conserved Domains (3) summary
      COG2319
      Location:323 → 593
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:333 → 371
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:129 → 157
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    6. XM_006498679.4 → XP_006498742.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

      UniProtKB/TrEMBL
      A2BFF8, Q3UDA2
      Conserved Domains (3) summary
      COG2319
      Location:303 → 573
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:313 → 351
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:109 → 137
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    7. XM_006498676.3 → XP_006498739.1  cytoplasmic dynein 1 intermediate chain 2 isoform X2

      UniProtKB/TrEMBL
      A2BFF5, Q3UDA2
      Related
      ENSMUSP00000107764.2, ENSMUST00000112136.2
      Conserved Domains (3) summary
      COG2319
      Location:329 → 599
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:339 → 377
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:135 → 163
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    8. XM_030247156.2 → XP_030103016.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

      UniProtKB/TrEMBL
      Q3UDA2
      Conserved Domains (3) summary
      COG2319
      Location:309 → 579
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:319 → 357
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:115 → 143
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    9. XM_030247151.2 → XP_030103011.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

      UniProtKB/TrEMBL
      Q3UDA2
      Conserved Domains (3) summary
      COG2319
      Location:323 → 593
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:333 → 371
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:129 → 157
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    RNA

    1. XR_004938034.1 RNA Sequence

    2. XR_004938032.1 RNA Sequence

    3. XR_004938033.1 RNA Sequence

    4. XR_004938035.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88487.1 GenPept UniProtKB/Swiss-Prot:O88487

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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