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    Zfp566 zinc finger protein 566 [ Mus musculus (house mouse) ]

    Gene ID: 72556, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp566provided by MGI
    Official Full Name
    zinc finger protein 566provided by MGI
    Primary source
    MGI:MGI:1919806
    See related
    Ensembl:ENSMUSG00000078768 AllianceGenome:MGI:1919806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mszf4; 2700043M03Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF566 (zinc finger protein 566). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 3.7), CNS E11.5 (RPKM 3.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp566 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29776762..29789935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30077337..30090510, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E8161 Neighboring gene zinc finger protein 82 Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene STARR-positive B cell enhancer ABC_E869 Neighboring gene zinc finger protein 260 Neighboring gene STARR-seq mESC enhancer starr_18505 Neighboring gene zinc finger protein 382

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Potential readthrough

    Included gene: Zfp82

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 566

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152814.2 → NP_690027.1  zinc finger protein 566

      See identical proteins and their annotated locations for NP_690027.1

      Status: VALIDATED

      Source sequence(s)
      AC157948, AC164703
      Consensus CDS
      CCDS52177.1
      UniProtKB/TrEMBL
      Q8VCI1
      Related
      ENSMUSP00000086164.5, ENSMUST00000088785.6
      Conserved Domains (6) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:193 → 355
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:167 → 189
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:237 → 262
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29776762..29789935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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