Mrc1 mannose receptor, C type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrc1provided by RGD
Official Full Name: mannose receptor, C type 1provided by RGD
Primary source: RGD:1309353
See related: Ensembl:ENSRNOG00000018251 AllianceGenome:RGD:1309353
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cargo receptor activity; mannose binding activity; and transmembrane signaling receptor activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within cellular response to interferon-gamma; cellular response to interleukin-4; and cellular response to lipopolysaccharide. Predicted to be located in cell surface and endosome membrane. Predicted to be active in plasma membrane. Orthologous to human MRC1 (mannose receptor C-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 395.8), Liver (RPKM 282.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (82157725..82239411)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (77249187..77330857)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (81352700..81433743)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study confirmed the occurrence of a mannose-specific C-type lectin receptor in olfactory ensheathing cells
Title: The mannose receptor is expressed by olfactory ensheathing cells in the rat olfactory bulb.
The HGF-beta.MR complex may provide a new pathway for the enhancement of cell clearance systems, which is associated with resolution of inflammation.
Title: Identification of mannose receptor as receptor for hepatocyte growth factor β-chain: novel ligand-receptor pathway for enhancing macrophage phagocytosis.
macrophage mannose receptor oligomerization enhances gp120-mediated binding of HIV-1
Title: Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macrophage mannose receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106123.2 → NP_001099593.2 macrophage mannose receptor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6JM56, D3ZD31

Related

ENSRNOP00000024736.8, ENSRNOT00000024736.8

Conserved Domains (5) summary

smart00059
Location:161 → 209

FN2; Fibronectin type 2 domain

cd00037
Location:659 → 779

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:362 → 487

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:27 → 142

RICIN; Ricin-type beta-trefoil

cd00161
Location:34 → 140

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...