Ephb6 Eph receptor B6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ephb6provided by RGD
Full Name: Eph receptor B6provided by RGD
Primary source: RGD:1306163
See related: Ensembl:ENSRNOG00000014367 AllianceGenome:RGD:1306163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHB6 (EPH receptor B6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 548.0), Adrenal (RPKM 241.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q23

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (71458632..71473889)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (70491973..70507230)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (70903253..70918514)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Ephb6 (e-PCR), detects polymorphism
- UniSTS:506884

UniSTS:495891 (e-PCR)
- UniSTS:495891

Ephb6 (e-PCR), detects polymorphism
- UniSTS:495891

RH129621 (e-PCR)
- UniSTS:212918

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type IV hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ephrin type-B receptor 6

Names: serine/arginine repetitive matrix protein 2-like; tyrosine-protein kinase-defective receptor EPH-6

NP_001101327.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107857.1 → NP_001101327.1 ephrin type-B receptor 6 precursor

See identical proteins and their annotated locations for NP_001101327.1

Status: PROVISIONAL

Source sequence(s)

CH473959

UniProtKB/Swiss-Prot

P0C0K7

UniProtKB/TrEMBL

A6IF46

Related

ENSRNOP00000019720.4, ENSRNOT00000019720.6

Conserved Domains (8) summary

cd09555
Location:937 → 1005

SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors

smart00454
Location:938 → 1004

SAM; Sterile alpha motif

cd10475
Location:33 → 225

EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6

cd00063
Location:480 → 571

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00185
Location:294 → 361

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

pfam07714
Location:662 → 907

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:604 → 657

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl21453
Location:657 → 911

PKc_like; Protein Kinases, catalytic domain