Mdr49 Multi drug resistance 49 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mdr49provided by FlyBase
Official Full Name: Multi drug resistance 49provided by FlyBase
Primary source: FLYBASE:FBgn0004512
Locus tag: Dmel_CG3879
See related: AllianceGenome:FB:FBgn0004512
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3879; Dm5; Dmel\CG3879; DmMdr49; mdr49; MDR49; MDR5; Mes5; mrd49
Summary: Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in several processes, including germ cell migration; renal tubular secretion; and response to hypoxia. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be integral component of membrane. Is expressed in head; mesoderm; stage 5 embryo; and wing disc. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); human immunodeficiency virus infectious disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 49E1-49E4; 2-67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12940323..12946347, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8827828..8833852, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

influences tolerance to insecticide exposure
Title: Describing the role of Drosophila melanogaster ABC transporters in insecticide biology using CRISPR-Cas9 knockouts.
the role of Mdr49 is to provide cholesterol for the correct processing of the Hh precursor protein.
Title: Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration.
Data support the hypothesis that the MDR49B isoform, with three amino acid mutations, plays a role in the early aspects of DDT resistance in 91-R.
Title: Splice form variant and amino acid changes in MDR49 confers DDT resistance in transgenic Drosophila.
mdr49 was expressed in larval tissues under stress conditions.
Title: Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal tubular secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
involved_in xenobiotic transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: multi drug resistance 49

Names: CG3879-PA; CG3879-PB; Mdr49-PA; Mdr49-PB

NP_001163132.1

EC 7.2.2.-

EC 7.6.2.2

NP_523724.2

EC 7.2.2.-

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12940323..12946347 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079000.4 → NP_523724.2 multi drug resistance 49, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523724.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RIT2, C1C3C4, Q00449, Q9V6I6

Related

FBpp0086914

Conserved Domains (3) summary

cd03249
Location:402 → 636

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

COG1132
Location:34 → 640

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

pfam00664
Location:116 → 352

ABC_membrane; ABC transporter transmembrane region
NM_001169661.1 → NP_001163132.1 multi drug resistance 49, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163132.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH49

Conserved Domains (5) summary

cd03249
Location:201 → 435

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

COG1126
Location:201 → 424

GlnQ; ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]

COG1132
Location:534 → 1098

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

pfam00664
Location:538 → 797

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:1 → 151

ABC_membrane; ABC transporter transmembrane region