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    nars1 asparaginyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568332, updated on 27-Mar-2024

    Summary

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    Official Symbol
    nars1provided by ZNC
    Official Full Name
    asparaginyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1016
    See related
    Ensembl:ENSDARG00000061100 AllianceGenome:ZFIN:ZDB-GENE-030131-1016
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nars; fb57a10; wu:fb57a10; si:dkey-274m14.2
    Summary
    Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in cytoplasm. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nars1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (944697..965598)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (776908..797242, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1b Neighboring gene thioredoxin-like 1 Neighboring gene scavenger receptor class B, member 2c Neighboring gene liver-expressed antimicrobial peptide 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA sequencing to study gene expression and SNP variations associated with growth in zebrafish fed a plant protein-based diet. Ulloa PE, et al. Mar Biotechnol (NY), 2015 Jun. PMID 25702041
    2. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414
    3. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Schüttler A, et al. Toxicol Sci, 2017 Jun 1. PMID 28329862, Free PMC Article
    4. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article
    5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within asparaginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    asparaginyl-tRNA synthetase, cytoplasmic; asparagine--tRNA ligase, cytoplasmic
    XP_696748.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      944697..965598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_691656.8 → XP_696748.4  asparagine--tRNA ligase, cytoplasmic

      UniProtKB/TrEMBL
      A0A8N7TDX3
      Related
      ENSDARP00000121524.1, ENSDART00000144766.2
      Conserved Domains (3) summary
      COG0017
      Location:168 → 603
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:280 → 599
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:182 → 264
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...
    Nucleotide Protein Strain
    Heading Accession and Version

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