mchr2b melanin concentrating hormone receptor 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mchr2bprovided by ZNC
Official Full Name: melanin concentrating hormone receptor 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030502-6
See related: Ensembl:ENSDARG00000036117 AllianceGenome:ZFIN:ZDB-GENE-030502-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mchr2; gpr145
Summary: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in integument. Orthologous to human MCHR2 (melanin concentrating hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (34806454..34823718)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (34920337..34937055)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.
Title: Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within background adaptation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melanin concentrating hormone receptor 2b; melanin-concentrating hormone receptor 2-like

Names: G protein-coupled receptor 145; G protein-coupled receptor mchr2; melanin-concentrating hormone receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423431.1 → NP_001410360.1 melanin concentrating hormone receptor 2b

Status: VALIDATED

Source sequence(s)

BX465217, CABZ01063786

UniProtKB/TrEMBL

A0A2R8QJ79, A0A8N7UUR8

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

34806454..34823718

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_681750.6 → XP_686842.2 melanin-concentrating hormone receptor 2-like

UniProtKB/TrEMBL

F1QR90

Related

ENSDARP00000152337.1, ENSDART00000188328.1

Conserved Domains (1) summary

pfam00001
Location:55 → 297

7tm_1; 7 transmembrane receptor (rhodopsin family)