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    Tlk2 tousled-like kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303592, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Tlk2provided by RGD
    Official Full Name
    tousled-like kinase 2provided by RGD
    Primary source
    RGD:1310907
    See related
    Ensembl:ENSRNOG00000006285 AllianceGenome:RGD:1310907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to be located in intermediate filament and perinuclear region of cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 106.8), Thymus (RPKM 93.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tlk2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (90648623..90748427)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90154449..90248562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (93410181..93507277)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 3 Neighboring gene U6 spliceosomal RNA Neighboring gene methyltransferase like 2 Neighboring gene cactin, spliceosome C complex subunit, pseudogene 2 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC120095186 Neighboring gene cytochrome c, somatic, pseudogene 6 Neighboring gene uncharacterized LOC120095187 Neighboring gene mannose receptor, C type 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Shalom S, et al. Mol Reprod Dev, 1999 Apr. PMID 10092119
    2. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. Yamakawa A, et al. Gene, 1997 Nov 20. PMID 9427565
    3. Nuclear localization of protein kinase U-alpha is regulated by 14-3-3. Zhang S, et al. J Biol Chem, 1999 Aug 27. PMID 10455159
    4. Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules. Yeh CH, et al. Biochem Biophys Res Commun, 2010 Sep 17. PMID 20705056
    5. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. Pilyugin M, et al. PLoS One, 2009 Dec 16. PMID 20016786, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleus localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase tousled-like 2
    NP_001178581.1
    XP_006247636.1
    XP_006247638.1
    XP_017452825.1
    XP_038942061.1
    XP_038942062.1
    XP_038942065.1
    XP_038942066.1
    XP_038942067.1
    XP_038942069.1
    XP_063125254.1
    XP_063125255.1
    XP_063125256.1
    XP_063125257.1
    XP_063125258.1
    XP_063125259.1
    XP_063125260.1
    XP_063125261.1
    XP_063125262.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191652.3 → NP_001178581.1  serine/threonine-protein kinase tousled-like 2

      See identical proteins and their annotated locations for NP_001178581.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LPP2
      Related
      ENSRNOP00000062555.2, ENSRNOT00000066484.3
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      90648623..90748427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247574.5 → XP_006247636.1  serine/threonine-protein kinase tousled-like 2 isoform X4

      See identical proteins and their annotated locations for XP_006247636.1

      UniProtKB/TrEMBL
      F1LPP2
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    2. XM_039086139.2 → XP_038942067.1  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GMB5
      Conserved Domains (2) summary
      COG1196
      Location:112 → 409
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:339 → 647
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    3. XM_039086133.2 → XP_038942061.1  serine/threonine-protein kinase tousled-like 2 isoform X4

      UniProtKB/TrEMBL
      F1LPP2
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    4. XM_039086138.2 → XP_038942066.1  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GMB5
      Conserved Domains (2) summary
      COG1196
      Location:112 → 409
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:339 → 647
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    5. XM_039086134.2 → XP_038942062.1  serine/threonine-protein kinase tousled-like 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZZQ4, A6HJX5, F1LPP2
      Related
      ENSRNOP00000084710.1
      Conserved Domains (2) summary
      COG1196
      Location:174 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:401 → 709
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    6. XM_063269191.1 → XP_063125261.1  serine/threonine-protein kinase tousled-like 2 isoform X12

    7. XM_039086137.2 → XP_038942065.1  serine/threonine-protein kinase tousled-like 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GMB5
      Conserved Domains (2) summary
      COG1196
      Location:136 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:363 → 671
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    8. XM_017597336.3 → XP_017452825.1  serine/threonine-protein kinase tousled-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GMB5
      Conserved Domains (2) summary
      COG1196
      Location:112 → 409
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:339 → 647
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    9. XM_063269192.1 → XP_063125262.1  serine/threonine-protein kinase tousled-like 2 isoform X14

    10. XM_063269190.1 → XP_063125260.1  serine/threonine-protein kinase tousled-like 2 isoform X9

    11. XM_063269187.1 → XP_063125257.1  serine/threonine-protein kinase tousled-like 2 isoform X5

    12. XM_063269186.1 → XP_063125256.1  serine/threonine-protein kinase tousled-like 2 isoform X3

    13. XM_063269184.1 → XP_063125254.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    14. XM_063269185.1 → XP_063125255.1  serine/threonine-protein kinase tousled-like 2 isoform X2

    15. XM_063269188.1 → XP_063125258.1  serine/threonine-protein kinase tousled-like 2 isoform X6

    16. XM_063269189.1 → XP_063125259.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    17. XM_006247576.5 → XP_006247638.1  serine/threonine-protein kinase tousled-like 2 isoform X4

      See identical proteins and their annotated locations for XP_006247638.1

      UniProtKB/TrEMBL
      F1LPP2
      Conserved Domains (2) summary
      COG1196
      Location:206 → 503
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:433 → 741
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

    18. XM_039086141.2 → XP_038942069.1  serine/threonine-protein kinase tousled-like 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I6GMB5
      Conserved Domains (2) summary
      COG1196
      Location:102 → 399
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14041
      Location:329 → 637
      STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    Nucleotide Protein Strain
    Heading Accession and Version

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