Eml2 EMAP like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eml2provided by RGD
Official Full Name: EMAP like 2provided by RGD
Primary source: RGD:621066
See related: Ensembl:ENSRNOG00000030127 AllianceGenome:RGD:621066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Emap; Eml1; Emap-2
Summary: Enables protein C-terminus binding activity and signaling receptor binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule polymerization; and regulation of microtubule nucleation. Predicted to be located in cytoplasm and microtubule. Predicted to colocalize with mitotic spindle. Orthologous to human EML2 (EMAP like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 167.7), Lung (RPKM 48.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87955924..87987366)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78827595..78859342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80087684..80118784)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in the expression of endothelial monocyteactivating polypeptide II in the rat hippocampus following status epilepticus.
Title: Changes in the expression of endothelial monocyte‑activating polypeptide II in the rat hippocampus following status epilepticus.
RhoA/ROCK signaling plays a role in endothelial-monocyte-activating polypeptide (EMAP) II-induced increase in blood-tumor barrier (BTB) permeability in rat brain microvascular endothelial cells.
Title: Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 2

Names: echinoderm microtubule associated protein like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414650.1 → NP_001401579.1 echinoderm microtubule-associated protein-like 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q6P6T4, Q8VIM8

Related

ENSRNOP00000075212.2, ENSRNOT00000078336.2
NM_138921.3 → NP_620276.3 echinoderm microtubule-associated protein-like 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8L2QPN8

Related

ENSRNOP00000046691.5, ENSRNOT00000041215.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

87955924..87987366

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093491.2 → XP_038949419.1 echinoderm microtubule-associated protein-like 2 isoform X1

UniProtKB/TrEMBL

A0A8I6B6G9

Conserved Domains (5) summary

COG2319
Location:267 → 688

WD40; WD40 repeat [General function prediction only]

sd00039
Location:401 → 438

7WD40; WD40 repeat [structural motif]

pfam03451
Location:210 → 282

HELP; HELP motif

cd21948
Location:59 → 106

TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2

cl29593
Location:564 → 838

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039093638.2 → XP_038949566.1 echinoderm microtubule-associated protein-like 2 isoform X4

UniProtKB/TrEMBL

A6J8K6

Conserved Domains (4) summary

sd00039
Location:301 → 349

7WD40; WD40 repeat [structural motif]

pfam03451
Location:211 → 283

HELP; HELP motif

cd21948
Location:59 → 106

TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2

cl29593
Location:291 → 513

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039093526.2 → XP_038949454.1 echinoderm microtubule-associated protein-like 2 isoform X2

UniProtKB/TrEMBL

A0A8I6B6G9

Conserved Domains (5) summary

COG2319
Location:222 → 643

WD40; WD40 repeat [General function prediction only]

sd00039
Location:356 → 393

7WD40; WD40 repeat [structural motif]

pfam03451
Location:165 → 237

HELP; HELP motif

cd21948
Location:13 → 60

TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2

cl29593
Location:519 → 793

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039093551.2 → XP_038949479.1 echinoderm microtubule-associated protein-like 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AQQ2, A0A8I6B6G9

Related

ENSRNOP00000096394.1

Conserved Domains (5) summary

COG2319
Location:221 → 642

WD40; WD40 repeat [General function prediction only]

sd00039
Location:355 → 392

7WD40; WD40 repeat [structural motif]

pfam03451
Location:164 → 236

HELP; HELP motif

cd21948
Location:13 → 60

TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2

cl29593
Location:518 → 792

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...