myo18aa myosin XVIIIAa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myo18aaprovided by ZNC
Official Full Name: myosin XVIIIAaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080425-5
See related: Ensembl:ENSDARG00000075752 AllianceGenome:ZFIN:ZDB-GENE-080425-5
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: myo18l2
Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within Golgi organization; cell-matrix adhesion; and muscle cell development. Predicted to be part of myosin complex. Is expressed in somite border. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (36950772..37075375, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (37006267..37131623, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Full loss of myo18b function results in a complete lack of sarcomeric structure, revealing a highly surprising and essential role for myo18b in sarcomere assembly. Importantly, scattered thin and thick filaments assemble throughout the sarcoplasm. These observations suggest a novel model of sarcomere assembly where Myo18b coordinates the integration of preformed thick and thin filaments into the sarcomere
Title: Myo18b is essential for sarcomere assembly in fast skeletal muscle.
MYO18A likely functions in the adhesion process that maintains the stable attachment of myofibers to ECM (extracellular matrix) and muscle integrity during early development
Title: The PDZ-containing unconventional myosin XVIIIA regulates embryonic muscle integrity in zebrafish.

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General gene information

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Markers

fj30f07.y1 (e-PCR)
- UniSTS:199021

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin XVIIIAa; unconventional myosin-XVIIIa

Names: myo18b; myosin XVIII-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

36950772..37075375 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305581.3 → XP_009303856.1 unconventional myosin-XVIIIa isoform X10

UniProtKB/TrEMBL

A0A8M3B6I5

Conserved Domains (9) summary

smart00242
Location:399 → 1165

MYSc; Myosin. Large ATPases

COG1340
Location:1509 → 1779

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:217 → 307

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:418 → 1153

MYSc_Myo18; class XVIII myosin, motor domain

pfam09728
Location:1666 → 1901

Taxilin; Myosin-like coiled-coil protein

pfam12325
Location:1229 → 1323

TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

pfam14662
Location:1373 → 1570

KASH_CCD; Coiled-coil region of CCDC155 or KASH

cl23720
Location:1466 → 1565

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23887
Location:1734 → 1868

DUF4349; Domain of unknown function (DUF4349)
XM_690164.9 → XP_695256.4 unconventional myosin-XVIIIa isoform X6

UniProtKB/TrEMBL

A0A0R4J7R2, A0A8N7T868

Related

ENSDARP00000118849.2, ENSDART00000132023.3

Conserved Domains (9) summary

smart00242
Location:399 → 1165

MYSc; Myosin. Large ATPases

COG1340
Location:1509 → 1779

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:217 → 307

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:418 → 1153

MYSc_Myo18; class XVIII myosin, motor domain

pfam09728
Location:1666 → 1901

Taxilin; Myosin-like coiled-coil protein

pfam12325
Location:1229 → 1323

TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

pfam14662
Location:1373 → 1570

KASH_CCD; Coiled-coil region of CCDC155 or KASH

cl23720
Location:1466 → 1565

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23887
Location:1734 → 1868

DUF4349; Domain of unknown function (DUF4349)
XM_021479432.1 → XP_021335107.1 unconventional myosin-XVIIIa isoform X5

UniProtKB/TrEMBL

A0A8M9PUB6

Conserved Domains (3) summary

cd01386
Location:448 → 1183

MYSc_Myo18; class XVIII myosin, motor domain

cl25800
Location:35 → 331

GGN; Gametogenetin

cl27381
Location:373 → 1920

Myosin_head; Myosin head (motor domain)
XM_021479431.1 → XP_021335106.1 unconventional myosin-XVIIIa isoform X4

UniProtKB/TrEMBL

A0A8M9QH80

Conserved Domains (3) summary

cd01386
Location:450 → 1185

MYSc_Myo18; class XVIII myosin, motor domain

cl26464
Location:36 → 375

Atrophin-1; Atrophin-1 family

cl27381
Location:375 → 1922

Myosin_head; Myosin head (motor domain)
XM_009305578.3 → XP_009303853.2 unconventional myosin-XVIIIa isoform X2

UniProtKB/TrEMBL

A0A8M3AX53

Conserved Domains (3) summary

cd01386
Location:472 → 1203

MYSc_Myo18; class XVIII myosin, motor domain

cl26464
Location:36 → 373

Atrophin-1; Atrophin-1 family

cl27381
Location:397 → 1940

Myosin_head; Myosin head (motor domain)
XM_021479434.1 → XP_021335109.1 unconventional myosin-XVIIIa isoform X9

UniProtKB/TrEMBL

A0A8M9QCN6

Conserved Domains (3) summary

cd01386
Location:472 → 1207

MYSc_Myo18; class XVIII myosin, motor domain

cl26464
Location:36 → 373

Atrophin-1; Atrophin-1 family

cl27381
Location:397 → 1944

Myosin_head; Myosin head (motor domain)
XM_009305579.3 → XP_009303854.2 unconventional myosin-XVIIIa isoform X3

UniProtKB/TrEMBL

A0A8M3BDA6

Conserved Domains (4) summary

cd01386
Location:472 → 1207

MYSc_Myo18; class XVIII myosin, motor domain

cl25574
Location:1769 → 2176

TOP2c; TopoisomeraseII

cl26464
Location:36 → 373

Atrophin-1; Atrophin-1 family

cl27381
Location:397 → 1944

Myosin_head; Myosin head (motor domain)
XM_009305580.3 → XP_009303855.2 unconventional myosin-XVIIIa isoform X8

UniProtKB/TrEMBL

A0A8M3AX31

Conserved Domains (3) summary

cd01386
Location:472 → 1207

MYSc_Myo18; class XVIII myosin, motor domain

cl26464
Location:36 → 373

Atrophin-1; Atrophin-1 family

cl27381
Location:397 → 1944

Myosin_head; Myosin head (motor domain)
XM_009305577.3 → XP_009303852.2 unconventional myosin-XVIIIa isoform X1

UniProtKB/TrEMBL

A0A8M9QL86

Conserved Domains (3) summary

cd01386
Location:472 → 1207

MYSc_Myo18; class XVIII myosin, motor domain

cl26464
Location:36 → 373

Atrophin-1; Atrophin-1 family

cl27381
Location:397 → 1944

Myosin_head; Myosin head (motor domain)
XM_021479430.1 → XP_021335105.1 unconventional myosin-XVIIIa isoform X1

UniProtKB/TrEMBL

A0A8M9QL86

Conserved Domains (3) summary

cd01386
Location:472 → 1207

MYSc_Myo18; class XVIII myosin, motor domain

cl26464
Location:36 → 373

Atrophin-1; Atrophin-1 family

cl27381
Location:397 → 1944

Myosin_head; Myosin head (motor domain)
XM_021479433.1 → XP_021335108.1 unconventional myosin-XVIIIa isoform X7

UniProtKB/TrEMBL

A0A8M9Q6N9

Conserved Domains (2) summary

cd01386
Location:128 → 863

MYSc_Myo18; class XVIII myosin, motor domain

cl27381
Location:99 → 1600

Myosin_head; Myosin head (motor domain)