scinlb scinderin like b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scinlbprovided by ZNC
Official Full Name: scinderin like bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2068
See related: Ensembl:ENSDARG00000058348 AllianceGenome:ZFIN:ZDB-GENE-040426-2068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77481; wu:fe16f08
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin nucleation and cell projection organization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including central nervous system; cornea; hatching gland; pancreatic system; and swim bladder. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10396379..10450792, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10612780..10667193, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that scinla and scinlb have different expression patterns and developmental roles during zebrafish development.
Title: Differential expression patterns and developmental roles of duplicated scinderin-like genes in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

Z9354 (e-PCR)
- UniSTS:21270

fj90b05.y1 (e-PCR)
- UniSTS:200265

fk31f12.y1 (e-PCR)
- UniSTS:200808

fe16f08.x1 (e-PCR)
- UniSTS:196252

fc24h04.y1 (e-PCR)
- UniSTS:193221

fj94b07.y1 (e-PCR)
- UniSTS:200391

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: scinderin like b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213090.2 → NP_998255.2 scinderin like b

Status: VALIDATED

Source sequence(s)

BX927121

UniProtKB/TrEMBL

A0A8M1PEJ5, A5PMZ3

Related

ENSDARP00000075639.3, ENSDART00000081196.4

Conserved Domains (6) summary

cd11288
Location:505 → 594

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:130 → 219

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:7 → 115

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:607 → 704

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:239 → 339

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:383 → 483

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins