ankrd6b ankyrin repeat domain 6b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ankrd6bprovided by ZNC
Official Full Name: ankyrin repeat domain 6bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030916-4
See related: Ensembl:ENSDARG00000029370 AllianceGenome:ZFIN:ZDB-GENE-030916-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ankrd6; diversin; si:dkey-181i3none
Summary: Acts upstream of or within several processes, including determination of ventral identity; gastrulation; and regulation of signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in liver. Orthologous to human ANKRD6 (ankyrin repeat domain 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (1203579..1239682, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (1182637..1218894, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrate that Diversin and Dishevelled function together in a mutually dependent fashion in zebrafish gastrulation and organ formation
Title: Diversin regulates heart formation and gastrulation movements in development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc19a05.x1 (e-PCR)
- UniSTS:192909

fc19a05.x1 (e-PCR)
- UniSTS:192910

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to beta-catenin binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 6; ankyrin repeat domain-containing protein 6b

Names: ankyrin repeat domain 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194423.2 → NP_919404.2 ankyrin repeat domain-containing protein 6b

Status: VALIDATED

Source sequence(s)

BX248418, EB936847

UniProtKB/TrEMBL

A0A8M1PB29, F6NJE0

Related

ENSDARP00000118157.1, ENSDART00000140650.3

Conserved Domains (5) summary

cd00204
Location:39 → 163

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam06640
Location:498 → 593

P_C; P protein C-terminus

pfam12796
Location:48 → 140

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:16 → 64

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:43 → 74

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

1203579..1239682 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468372.1 → XP_021324047.1 ankyrin repeat domain-containing protein 6 isoform X1

UniProtKB/TrEMBL

A0A8M9P2G9

Conserved Domains (4) summary

cd00204
Location:65 → 185

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:65 → 96

ANK; ANK repeat [structural motif]

cl26072
Location:214 → 293

Ank_5; Ankyrin repeats (many copies)

cl26386
Location:554 → 721

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III