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    Send2 Spermathecal endopeptidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34836, updated on 10-May-2024

    Summary

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    Official Symbol
    Send2provided by FlyBase
    Official Full Name
    Spermathecal endopeptidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0264253
    Locus tag
    Dmel_CG18125
    See related
    AllianceGenome:FB:FBgn0264253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS01068.10; CG18125; Dmel\CG18125; DS01068.10; SP190; SPH190
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermathecum. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Send2 in Genome Data Viewer
    Location:
    35A4-35A4; 2-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14345915..14346688, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14345915..14346688, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene male sterile (2) 34Fe Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44850 Neighboring gene mitochondrial transcription termination factor Neighboring gene lethal (2) 34Fc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics reveals rapid divergence in the postmating response of female reproductive tracts among sibling species. McCullough EL, et al. Proc Biol Sci, 2020 Jun 24. PMID 32576111, Free PMC Article
    2. Sperm-storage defects and live birth in Drosophila females lacking spermathecal secretory cells. Schnakenberg SL, et al. PLoS Biol, 2011 Nov. PMID 22087073, Free PMC Article
    3. Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size. Wegman LJ, et al. Dev Biol, 2010 Sep 15. PMID 20630480, Free PMC Article
    4. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377
    5. Temporal coordination of gene networks by Zelda in the early Drosophila embryo. Nien CY, et al. PLoS Genet, 2011 Oct. PMID 22028675, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spermathecal endopeptidase 2
    Names
    CG18125-PA
    Send2-PA
    NP_609708.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14345915..14346688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135864.3 → NP_609708.2  spermathecal endopeptidase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609708.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7DZ43, A7DZ55, Q7KT95
      Related
      FBpp0080214
      Conserved Domains (2) summary
      smart00020
      Location:26 → 225
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:27 → 225
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KT95 Q7KT95

    Gene LinkOut

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