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    BHLHE41 basic helix-loop-helix family member e41 [ Canis lupus familiaris (dog) ]

    Gene ID: 403457, updated on 5-Mar-2024

    Summary

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    Official Symbol
    BHLHE41provided by VGNC
    Official Full Name
    basic helix-loop-helix family member e41provided by VGNC
    Primary source
    VGNC:VGNC:57419
    See related
    Ensembl:ENSCAFG00845026188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    DEC2; BHLHB3; SHARP1
    Orthologs
    human mouse all
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    Genomic context

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    See BHLHE41 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (21659233..21663998)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (24913768..24918529, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (25081155..25085938, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (21469068..21473810)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (21491838..21496575)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor type 2 Neighboring gene sarcospan Neighboring gene uncharacterized LOC102152522 Neighboring gene Ras association domain family member 8 Neighboring gene 60S ribosomal protein L10a-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of canine SHARP1 and its evaluation as a positional candidate for canine early retinal degeneration (erd). Kukekova AV, et al. Gene, 2003 Jul 17. PMID 12909371
    2. Genome-wide identification and analysis of basic helix-loop-helix domains in dog, Canis lupus familiaris. Wang XH, et al. Mol Genet Genomics, 2015 Apr. PMID 25403511

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    class E basic helix-loop-helix protein 41
    Names
    basic helix-loop-helix domain containing, class B, 3
    basic helix-loop-helix domain containing, class B3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002973.1 → NP_001002973.1  class E basic helix-loop-helix protein 41

      See identical proteins and their annotated locations for NP_001002973.1

      Status: PROVISIONAL

      Source sequence(s)
      AY204568
      UniProtKB/TrEMBL
      A0A8C0KKV3, A0A8C0PIK1, Q7YQC9
      Related
      ENSCAFP00845036319.1, ENSCAFT00845046252.1
      Conserved Domains (2) summary
      cd00083
      Location:46 → 104
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:131 → 171
      Hairy_orange; Hairy Orange

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      21659233..21663998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      21469068..21473810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      21491838..21496575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      25081155..25085938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      24913768..24918529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials