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    CALCA calcitonin related polypeptide alpha [ Canis lupus familiaris (dog) ]

    Gene ID: 403946, updated on 5-Mar-2024

    Summary

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    Gene symbol
    CALCA
    Gene description
    calcitonin related polypeptide alpha
    See related
    Ensembl:ENSCAFG00845023464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    CALC; CCALCI; CGRP-I
    Orthologs
    human mouse all
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    Genomic context

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    See CALCA in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (39008930..39013844)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (37414591..37419526)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (38519171..38524051)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (38026272..38031153)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (38231378..38236258)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152988 Neighboring gene calcitonin receptor-stimulating peptide-2 Neighboring gene INSC spindle orientation adaptor protein Neighboring gene uncharacterized LOC111091612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis and chromosomal assignment of the canine CALC-I/alpha-CGRP gene. Wende S, et al. Mamm Genome, 2000 Sep. PMID 10967131
    2. Detection of a polymorphic 27 bp insertion/deletion in exon 4 of the canine calcitonin/calcitonin gene-related peptide gene I (CALCA). Wende S, et al. Anim Genet, 2000 Jun. PMID 10895326
    3. Elucidation of the sequence of canine (pro)-calcitonin. A molecular biological and protein chemical approach. Mol JA, et al. Regul Pept, 1991 Sep 3. PMID 1758974

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcitonin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcitonin
    Names
    alpha-type CGRP
    calcitonin gene-related peptide 1
    calcitonin gene-related peptide I
    calcitonin/calcitonin-related polypeptide, alpha
    prepro-alpha-calcitonin gene-related peptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313790.2 → NP_001300719.1  calcitonin isoform 1 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      DN347171, DN347405, DN347413, DN348984
      UniProtKB/Swiss-Prot
      Q9MYV1
      UniProtKB/TrEMBL
      A0A8C0KUX6
      Related
      ENSCAFP00845032491.1, ENSCAFT00845041436.1
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 124
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    2. NM_001313791.2 → NP_001300720.1  calcitonin isoform 1 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      DN347413, DN347479, DN348984
      UniProtKB/Swiss-Prot
      Q9MYV1
      UniProtKB/TrEMBL
      A0A8C0KUX6
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 124
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      39008930..39013844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429455.1 → XP_038285383.1  calcitonin isoform X1

      UniProtKB/Swiss-Prot
      P41547, Q9MYV2
      Related
      ENSCAFP00845032532.1, ENSCAFT00845041491.1
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      38026272..38031153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      38231378..38236258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      38519171..38524051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37414591..37419526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003266.2: Suppressed sequence

      Description
      NM_001003266.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41547.2 GenPept UniProtKB/Swiss-Prot:P41547
    Q9MYV1.1 GenPept UniProtKB/Swiss-Prot:Q9MYV1

    Gene LinkOut

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