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    PTPN11 protein tyrosine phosphatase non-receptor type 11 [ Canis lupus familiaris (dog) ]

    Gene ID: 477488, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PTPN11provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 11provided by VGNC
    Primary source
    VGNC:VGNC:45168
    See related
    Ensembl:ENSCAFG00845021271
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    SHP-2
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN11 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (10229100..10311852)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (10107654..10190288)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (10314568..10397234)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (10203528..10286110)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (10266437..10349406)

    Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene uncharacterized LOC119866153 Neighboring gene ribosomal protein L6 Neighboring gene uncharacterized LOC119866090 Neighboring gene uncharacterized LOC111092664

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PTPN11 mutations in canine and human disseminated histiocytic sarcoma. Hédan B, et al. Int J Cancer, 2020 Sep 15. PMID 32212266
    2. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Wang CZ, et al. Mol Biol Cell, 2006 Jun. PMID 16611743, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
      Title: PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 11
    Names
    protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
    XP_005636307.1
    XP_005636308.1
    XP_038292668.1
    XP_038292669.1
    XP_038367582.1
    XP_038367583.1
    XP_038431076.1
    XP_038431077.1
    XP_038495260.1
    XP_038495261.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051830.1 Reference ROS_Cfam_1.0

      Range
      10229100..10311852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038436740.1 → XP_038292668.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TMZ0, A0A8I3PMT9
      Related
      ENSCAFP00845029515.1, ENSCAFT00845037668.1
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    2. XM_038436741.1 → XP_038292669.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

      UniProtKB/TrEMBL
      A0A8C0TMZ0, A0A8I3P833
      Related
      ENSCAFP00845029696.1, ENSCAFT00845037897.1
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049286.1 Alternate UMICH_Zoey_3.1

      Range
      10203528..10286110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038511654.1 → XP_038367582.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    2. XM_038511655.1 → XP_038367583.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

      Range
      10266437..10349406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038639332.1 → XP_038495260.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    2. XM_038639333.1 → XP_038495261.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

      Range
      10314568..10397234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038575148.1 → XP_038431076.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TMQ6, A0A8C0TMZ0
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    2. XM_038575149.1 → XP_038431077.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

      UniProtKB/TrEMBL
      A0A4D6PF96, A0A8C0TMZ0
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      10107654..10190288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005636250.3 → XP_005636307.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

      UniProtKB/TrEMBL
      A0A8C0TMQ6, A0A8C0TMZ0
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    2. XM_005636251.3 → XP_005636308.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

      UniProtKB/TrEMBL
      A0A4D6PF96, A0A8C0TMZ0
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
    Nucleotide Protein
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