PLXND1 plexin D1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PLXND1provided by VGNC
Official Full Name: plexin D1provided by VGNC
Primary source: VGNC:VGNC:44726
See related: Ensembl:ENSCAFG00845026992
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (5584594..5640188)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (5592327..5647912)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (5629100..5684701)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (5300473..5356062)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (5653488..5707957)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_12353-12354:997214187:1 (e-PCR)
- UniSTS:267419

D10Bir17 (e-PCR), detects polymorphism
- UniSTS:141482

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of axonogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of semaphorin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: plexin-D1; LOW QUALITY PROTEIN: plexin-D1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051824.1 Reference ROS_Cfam_1.0

Range

5584594..5640188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038426879.1 → XP_038282807.1 plexin-D1

UniProtKB/TrEMBL

A0A8C0QWG5, A0A8I3SAM2

Related

ENSCAFP00845037580.1, ENSCAFT00845047906.1

Conserved Domains (8) summary

cd11247
Location:53 → 551

Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1

smart00423
Location:705 → 757

PSI; domain found in Plexins, Semaphorins and Integrins

cd01180
Location:894 → 982

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1072 → 1177

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:553 → 605

PSI; Plexin repeat

pfam08337
Location:1348 → 1891

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:611 → 704

TIG_plexin; TIG domain

cl15674
Location:984 → 1070

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049280.1 Alternate UMICH_Zoey_3.1

Range

5300473..5356062

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038502674.1 → XP_038358602.1 plexin-D1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049761.1 Alternate UNSW_CanFamBas_1.0

Range

5653488..5707957

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038629725.1 → XP_038485653.1 LOW QUALITY PROTEIN: plexin-D1

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049241.1 Alternate UU_Cfam_GSD_1.0

Range

5629100..5684701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038565591.1 → XP_038421519.1 LOW QUALITY PROTEIN: plexin-D1

UniProtKB/TrEMBL

A0A8C0QWG5

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

5592327..5647912

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038455492.1 → XP_038311420.1 plexin-D1

UniProtKB/TrEMBL

A0A8C0QWG5, A0A8I3SAM2

Conserved Domains (8) summary

cd11247
Location:53 → 551

Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1

smart00423
Location:705 → 757

PSI; domain found in Plexins, Semaphorins and Integrins

cd01180
Location:894 → 982

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1072 → 1177

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:553 → 605

PSI; Plexin repeat

pfam08337
Location:1348 → 1891

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:611 → 704

TIG_plexin; TIG domain

cl15674
Location:984 → 1070

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...