hsd11b2 hydroxysteroid (11-beta) dehydrogenase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd11b2provided by ZNC
Official Full Name: hydroxysteroid (11-beta) dehydrogenase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6030
See related: Ensembl:ENSDARG00000001975 AllianceGenome:ZFIN:ZDB-GENE-030131-6030
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: 11-DH2; wu:fi31d01
Summary: Predicted to enable oxidoreductase activity. Acts upstream of or within cortisol metabolic process and multicellular organismal response to stress. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; endocrine system; and eye. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (35112052..35126343, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (34840575..34854866, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults.
Title: Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults.
Our experiments show that 20b-HSD type 2, together with 11b-HSD type 2, represents a short pathway in zebrafish to rapidly inactivate and excrete cortisol. Therefore, 20beta-HSD type 2 is an important enzyme in stress response
Title: Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response.
Sequence comparison revealed the presence of an alanine at position 253 on zebrafish 11beta-HSD2, corresponding to cysteine-264 in the substratebinding pocket of the human enzyme
Title: Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins.

Submit: New GeneRIF Correction

General gene information

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Markers

fi31d01.x1 (e-PCR)
- UniSTS:197260

AW175018 (e-PCR)
- UniSTS:205786

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cortisol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cortisol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucocorticoid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 11-beta-hydroxysteroid dehydrogenase type 2

Names: 11-HSD type II; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2

NP_997885.2

EC 1.1.1.146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212720.2 → NP_997885.2 11-beta-hydroxysteroid dehydrogenase type 2

Status: PROVISIONAL

Source sequence(s)

BC065613

UniProtKB/Swiss-Prot

F1QLP1, Q6P0H9

Related

ENSDARP00000118501.1, ENSDART00000141211.2

Conserved Domains (2) summary

cd09805
Location:86 → 366

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:86 → 279

adh_short; short chain dehydrogenase